"Every form of neural activity depends on temperature, yet its
relationship to brain rhythms is poorly understood. In this work we
examined how sleep spindles are influenced by changing brain
temperatures and how brain temperature is influenced by sleep
oscillations. We employed a novel thermoelectrode designed for
measuring temperature while recording neural activity. We found that
spindle frequency is positively correlated and duration negatively
correlated with brain temperature. Local heating of the thalamus
replicated the temperature dependence of spindle parameters in the
heated area only, suggesting biophysical rather than global modulatory
mechanisms, a finding also supported by a thalamic network
model. Finally, we show that switches between oscillatory states also
influence brain temperature on a shorter and smaller scale. Epochs of
paradoxical sleep as well as the infra-slow oscillation were
associated with brain temperature fluctuations below 0.2°C. Our
results highlight that brain temperature is massively intertwined with
sleep oscillations on various time scales."
Reference:
1 .
Csernai M, Borbély S, Kocsis K, Burka D, Fekete Z, Balogh V, Káli S, Emri Z, Barthó P (2019) Dynamics of sleep oscillations is coupled to brain temperature on multiple scales. J Physiol [PubMed]
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