Human tactile FA1 neurons (Hay and Pruszynski 2020)

 Download zip file 
Help downloading and running models
"... we show that synaptic integration across the complex signals from the first-order neuronal population could underlie human ability to accurately (< 3°) and rapidly process the orientation of edges moving across the fingertip. We first derive spiking models of human first-order tactile neurons that fit and predict responses to moving edges with high accuracy. We then use the model neurons in simulating the peripheral neuronal population that innervates a fingertip. We train classifiers performing synaptic integration across the neuronal population activity, and show that synaptic integration across first-order neurons can process edge orientations with high acuity and speed. ... our models suggest that integration of fast-decaying (AMPA-like) synaptic inputs within short timescales is critical for discriminating fine orientations, whereas integration of slow-decaying (NMDA-like) synaptic inputs supports discrimination of coarser orientations and maintains robustness over longer timescales"
1 . Hay E, Pruszynski JA (2020) Orientation processing by synaptic integration across first-order tactile neurons. PLoS Comput Biol 16:e1008303 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Realistic Network;
Brain Region(s)/Organism: Human;
Cell Type(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Simulation Environment: MATLAB;
Model Concept(s): Sensory coding; Synaptic Integration; Receptive field;
Search NeuronDB for information about:  AMPA; NMDA;
% Author: Etay Hay
% Orientation processing by synaptic integration across first-order tactile neurons (Hay and Pruszynski 2020)

function N_plateau = get_Nmr_plateau(cellnum,Nmrs,model_type)
	paccs = [];
	NuniqueMR = [];
	for k = 1:length(Nmrs)
		[model,ws,perrs] = cell2model(cellnum,Nmrs(k),model_type);
		paccs(k,:) = max(0,round(100 - perrs));
		NuniqueMR(k) = length(model.mr_w);
	best_pacc = 0;
	for k = 1:length(Nmrs)
		if (mean(paccs(k,:)) - best_pacc) >= (5/size(paccs,2))
			N_plateau = NuniqueMR(k);
			best_pacc = mean(paccs(k,:));