A cerebellar model of phase-locked tACS for essential tremor (Schreglmann et al., 2021)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:266842
This model is a supplementary material for Schreglmann, Sebastian R., et al. "Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence" Nature Communications (2021). The model demonstrates that phase-locked transcranial alternating current stimulation (tACS) is able to disrupt the tremor-related oscillations in the cerebellum, and its efficacy is highly dependent on the relative phase between the stimulation and tremor.
Reference:
1 . Schreglmann S, Wang D, Peach R, Li J, Zhang X, Latorre A, Rhodes E, Panella E, Boyden ES, Barahona M, Santaniello S, Bhatia KP, Rothwell J, Grossman N (2021) Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence Nature Communications 12:363 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum deep nucleus neuron; Inferior olive neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell;