Gamma oscillations in hippocampal interneuron networks (Wang, Buzsaki 1996)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:26997
The authors investigated the hypothesis that 20-80Hz neuronal (gamma) oscillations can emerge in sparsely connected network models of GABAergic fast-spiking interneurons. They explore model NN synchronization and compare their results to anatomical and electrophysiological data from hippocampal fast spiking interneurons.
Reference:
1 . Wang XJ, Buzsáki G (1996) Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. J Neurosci 16:6402-13 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Abstract Wang-Buzsaki neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]; Lytton, William [bill.lytton at downstate.edu];
Search NeuronDB for information about:  GabaA; I Na,t; I K;
NEURON { SUFFIX kdr }
NEURON { USEION k WRITE ik }         
ASSIGNED { ik }
PARAMETER {
	erev 		= -90.  (mV)
	gmax 		= 0.009    (mho/cm2)
        vrest           = 0.

	exptemp		= 27
	maflag 		= 3
	malphaA 	= -0.01
	malphaB		= -10.0
	malphaV0	= -34.
	mbflag 		= 1
	mbetaA 		= 0.125
	mbetaB		= -80.
	mbetaV0		= -44.
	mq10		= 5
	mexp 		= 4

	haflag 		= 0
	halphaA 	= 0
	halphaB		= 0
	halphaV0	= 0
	hbflag 		= 0
	hbetaA 		= 0
	hbetaB		= 0
	hbetaV0		= 0
	hq10		= 5
	hexp 		= 0

	cao                (mM)
	cai                (mM)

	celsius			   (degC)
	dt 				   (ms)
	v 			       (mV)

	vmax 		= 100  (mV)
	vmin 		= -100 (mV)
} : end PARAMETER

INCLUDE "geneval_cvode.inc"

PROCEDURE iassign () { i = g*(v-erev) ik=i }

:* SYNAPSES
:** AMPA