Inhibitory control by an integral feedback signal in prefrontal cortex (Miller and Wang 2006)

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The prefrontal cortex (PFC) is known to be critical for inhibitory control of behavior, but the underlying mechanisms are unclear. Here, we propose that inhibitory control can be instantiated by an integral signal derived from working memory, another key function of the PFC. Specifically, we assume that an integrator converts excitatory input into a graded mnemonic activity that provides an inhibitory signal (integral feedback control) to upstream afferent neurons. We demonstrate this scenario in a neuronal-network model for a temporal discrimination task... See paper for details and more.
1 . Miller P, Wang XJ (2006) Inhibitory control by an integral feedback signal in prefrontal cortex: A model of discrimination between sequential stimuli. Proc Natl Acad Sci U S A 103(1):201-6 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Prefrontal cortex (PFC);
Cell Type(s):
Gap Junctions:
Simulation Environment: XPP; C or C++ program (web link to model);
Model Concept(s): Pattern Recognition; Activity Patterns; Simplified Models; Working memory; Action Selection/Decision Making;
Implementer(s): Miller, Paul [pmiller at];