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Inhibitory control by an integral feedback signal in prefrontal cortex (Miller and Wang 2006)
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The prefrontal cortex (PFC) is known to be critical for inhibitory control of behavior, but the underlying mechanisms are unclear. Here, we propose that inhibitory control can be instantiated by an integral signal derived from working memory, another key function of the PFC. Speciﬁcally, we assume that an integrator converts excitatory input into a graded mnemonic activity that provides an inhibitory signal (integral feedback control) to upstream afferent neurons. We demonstrate this scenario in a neuronal-network model for a temporal discrimination task... See paper for details and more.
Miller P, Wang XJ (2006) Inhibitory control by an integral feedback signal in prefrontal cortex: A model of discrimination between sequential stimuli.
Proc Natl Acad Sci U S A
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Prefrontal cortex (PFC);
C or C++ program (web link to model);
Action Selection/Decision Making;
Miller, Paul [pmiller at brandeis.edu];
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