Networks of spiking neurons: a review of tools and strategies (Brette et al. 2007)

 Download zip file   Auto-launch 
Help downloading and running models
This package provides a series of codes that simulate networks of spiking neurons (excitatory and inhibitory, integrate-and-fire or Hodgkin-Huxley type, current-based or conductance-based synapses; some of them are event-based). The same networks are implemented in different simulators (NEURON, GENESIS, NEST, NCS, CSIM, XPP, SPLIT, MVAspike; there is also a couple of implementations in SciLab and C++). The codes included in this package are benchmark simulations; see the associated review paper (Brette et al. 2007). The main goal is to provide a series of benchmark simulations of networks of spiking neurons, and demonstrate how these are implemented in the different simulators overviewed in the paper. See also details in the enclosed file Appendix2.pdf, which describes these different benchmarks. Some of these benchmarks were based on the Vogels-Abbott model (Vogels TP and Abbott LF 2005).
1 . Vogels TP, Abbott LF (2005) Signal propagation and logic gating in networks of integrate-and-fire neurons. J Neurosci 25:10786-95 [PubMed]
2 . Brette R, Rudolph M, Carnevale T, Hines M, Beeman D, Bower JM, Diesmann M, Morrison A, Goodman PH, Harris FC, Zirpe M, Natschl├Ąger T, Pecevski D, Ermentrout B, Djurfeldt M, Lansner A, Rochel O, Vieville T, Muller E, Davison AP, El Boustani S, Destexhe A (2007) Simulation of networks of spiking neurons: a review of tools and strategies. J Comput Neurosci 23:349-98 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Abstract integrate-and-fire leaky neuron;
Gap Junctions:
Simulation Environment: NEURON; GENESIS; NEST; C or C++ program; XPP; CSIM; NCS; SPLIT; MVASpike; SciLab; Brian; PyNN; Python;
Model Concept(s): Activity Patterns; Methods;
Implementer(s): Carnevale, Ted [Ted.Carnevale at]; Hines, Michael [Michael.Hines at]; Davison, Andrew [Andrew.Davison at]; Destexhe, Alain [Destexhe at]; Ermentrout, Bard []; Brette R; Bower, James; Beeman, Dave; Diesmann M; Morrison A ; Goodman PH; Harris Jr, FC; Zirpe M ; Natschlager T ; Pecevski D ; Djurfeldt M; Lansner, Anders [ala at]; Rochel O ; Vieville T ; Muller E ; El Boustani, Sami [elboustani at]; Rudolph M ;
#define N 4000

#define T 5.0
#define DT 1e-4
#define PRINT_EVERY_NTH 100

#define cell_area 20000e-12
#define tau_m        20e-3
#define C_m           1e-2
#define rho_leak      5e-1
#define Erev_leak   -65e-3

#define Gexc	      6e-9
#define Ginh	     67e-9
#define Erev_exc      0
#define Erev_inh    -80e-3
#define tau_exc       5e-3
#define tau_inh      10e-3

#define conn_prob     0.02
#define conn_delay    1e-6 // arbitrary non-zero

#define gNa	     0.1e4
#define gKd	    0.03e4
#define ENa	     50e-3
#define EK	    -90e-3
#define Vtr	    -63e-3

#define N_e ((int) (0.8 * N))
#define N_i (N - N_e)

#include <iostream>
#include <cmath>

#include <split.hh>
#include <split/connection-set.hh>

using namespace libsplit;

class projection;

class cells
  split_int* split;
  int _pop_id;
  int _leak_id;
  int _na_id;
  int _k_id;
  int _size;

  cells (split_int* _split, int size);
  int pop_id () { return _pop_id; }
  int na_id () { return _na_id; }
  int size () { return _size; }
  projection* project (cells* post);
  void set_parameters ();

class projection
  split_int* split;
  int proj_id;
  connection_set c;
  projection (split_int* _split, cells& pre, cells& post)
    : split (_split), c (random_uniform (conn_prob))
    c.init (0, pre.size (), 0, post.size ());
    proj_id = split->create_projection (CHEMICAL_SYNAPSE, SCALAR,
					pre.pop_id (), CONTRIB, pre.na_id (),
					post.pop_id (), 0,
					c.size ());
    for (c.begin (); !c.end (); ++c)
	split->set_projection_index_int (proj_id, SYN_PRE, (), c.pre ());
	split->set_projection_index_int (proj_id, SYN_POST, (), ());
	split->set_projection_index_real (proj_id, SYN_DELAY, (),
  void set_parameters (double G, double Erev, double tau)
    split->set_projection_scalar_real (proj_id, SYN_E, Erev);
    split->set_projection_scalar_real (proj_id, SYN_DURATION, 0.0);
    split->set_projection_scalar_real (proj_id, SYN_RAISE, 0.0);
    split->set_projection_scalar_real (proj_id, SYN_DECAY, tau);
    for (c.begin (); !c.end (); ++c)
      split->set_projection_index_real (proj_id, SYN_G, (), G);

cells::cells (split_int* _split, int size)
  : split (_split), _size (size)
  int tree_map[1] = { 0 };
  _pop_id = split->create_population ();
  split->create_electric_tree (_pop_id, ELECTRIC_SCALAR_STAR, N_e, 0, 0,
			       tree_map /* dummy */ );
  _leak_id = split->create_e_leak (_pop_id, N_e, 0);
  _na_id = split->create_simple_channel (_pop_id, TRAUB_NA, SCALAR, N_e, 0);
  _k_id = split->create_simple_channel (_pop_id, HH_K, SCALAR, N_e, 0);

cells::project (cells* post)
  return new projection (split, *this, *post);
cells::set_parameters ()
  split->set_scalar_real (_pop_id, ELECTRIC, 0, CM, cell_area * C_m);
  split->set_scalar_real (_pop_id, ELECTRIC, 0, GCORE, 0);
  split->set_scalar_real (_pop_id, CONTRIB, _leak_id, E_LEAK_E, Erev_leak);
  for (int i = 0; i < _size; ++i)
      split->set_index_real (_pop_id, ELECTRIC, 0, INITIAL, i, Erev_leak);
      split->set_index_real (_pop_id, CONTRIB, _leak_id,
			     E_LEAK_G_M, i, cell_area * rho_leak);

  // Na activation
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_ALPHA_A, 0.32e6);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_ALPHA_B, 13e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_ALPHA_C, 4e-3);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_BETA_A, 0.28e6);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_BETA_B, 40e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  ACT_BETA_C, 5e-3);
  split->set_scalar_int (_pop_id, CONTRIB, _na_id,
			 ACT_EXPO, 3);
  // Na inactivation
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_ALPHA_A, 0.128e3);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_ALPHA_B, 17e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_ALPHA_C, 18e-3);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_BETA_A, 4e3);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_BETA_B, 40e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _na_id,
			  INACT_BETA_C, 5e-3);
  split->set_scalar_int (_pop_id, CONTRIB, _na_id,
			 INACT_EXPO, 1);
  // K
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_ALPHA_A, 0.032e6);
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_ALPHA_B, 15e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_ALPHA_C, 5e-3);
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_BETA_A, 0.5e3);
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_BETA_B, 10e-3 + Vtr);
  split->set_scalar_real (_pop_id, CONTRIB, _k_id,
			  ACT_BETA_C, 40e-3);
  split->set_scalar_int (_pop_id, CONTRIB, _k_id,
			 ACT_EXPO, 4);

  for (int i = 0; i < _size; ++i)
      // Na
      split->set_index_real (_pop_id, CONTRIB, _na_id,
			     CHAN_E, i, ENa);
      split->set_index_real (_pop_id, CONTRIB, _na_id,
			     CHAN_G, i, cell_area * gNa);
      // K
      split->set_index_real (_pop_id, CONTRIB, _k_id,
			     CHAN_E, i, EK);
      split->set_index_real (_pop_id, CONTRIB, _k_id,
			     CHAN_G, i, cell_area * gKd);

class noise {
  split_int* split;
  cells* c;
  int id;
  noise (split_int*  _split, cells* _c)
    : split (_split), c (_c)
    id = split->create_noise (c->pop_id (), c->size (), 0);
  void set_parameters ()
    for (int i = 0; i < c->size (); ++i)
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_E, i, 0);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_G, i, 7.5e-10);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_INTENSITY, i, 100);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_INITIAL, i, 0);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_TAU, i, 0.01);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_START_TIME, i, 0);
	split->set_index_real (c->pop_id (), CONTRIB, id,
			       NOISE_END_TIME, i, 0.05);

setup_volts_plot (split_int* split, int id, cells* c, int n, int& idx)
  for (int i = 0; i < n; ++i)
      split->set_plot_index_int (id, idx, PLOT_ID, 0);
      split->set_plot_index_int (id, idx, PLOT_POP_ID, c->pop_id ());
      split->set_plot_index_int (id, idx, PLOT_TYPE, ELECTRIC);
      split->set_plot_index_int (id, idx, PLOT_TAG, STATE_SV);
      split->set_plot_index_int (id, idx, PLOT_IDX, i);
      split->set_plot_index_real (id, idx, PLOT_MIN, -0.08);
      split->set_plot_index_real (id, idx, PLOT_MAX, 0.05);

main (int argc, char **argv)
  std::cout << "Setup\n";
  split_int* split = new split_int (&argc, &argv);
  // Create cells
  cells* ecells = new cells (split, N_e);
  cells* icells = new cells (split, N_i);
  // Create synapses
  projection* ee = ecells->project (ecells);
  projection* ei = ecells->project (icells);
  projection* ii = icells->project (icells);
  projection* ie = icells->project (ecells);

  // Noiseinjection
  noise* enoise = new noise (split, ecells);
  noise* inoise = new noise (split, icells);
  // Volt plots
  int volts_id = split->create_plot ("volts.out",
  split->set_plot_scalar_int (volts_id, PLOT_EVERY_NTH, 1);
  int idx = 0;
  setup_volts_plot (split, volts_id, ecells, N_PLOTTED_ECELLS, idx);
  setup_volts_plot (split, volts_id, icells, N_PLOTTED_ICELLS, idx);
  // Spike plot
  int spikes_id = split->create_spike_plot_ranges ("spikes.out");
  split->set_plot_range (spikes_id, ecells->pop_id (), ELECTRIC, 0,
			 STATE_SV, 0, ecells->size ());
  split->set_plot_range (spikes_id, icells->pop_id (), ELECTRIC, 0,
			 STATE_SV, 0, icells->size ());
  // Distribute simulation onto slaves
  split->map (0);
  // Cell parameters
  ecells->set_parameters ();
  icells->set_parameters ();
  // Synaptic parameters
  ee->set_parameters (Gexc, Erev_exc, tau_exc);
  ei->set_parameters (Gexc, Erev_exc, tau_exc);
  ii->set_parameters (Ginh, Erev_inh, tau_inh);
  ie->set_parameters (Ginh, Erev_inh, tau_inh);

  // Noise parameters
  enoise->set_parameters ();
  inoise->set_parameters ();
  // Allocate
  split->allocate (0.0, T, DT);
  // Initialize
  split->initialize (DT);
  // Simulate
  std::cout << "Simulate\n";
  int total_steps = (int) ceil (T / DT);
  for (int steps = 0; steps < total_steps; steps += PRINT_EVERY_NTH)
    split->simulate (PRINT_EVERY_NTH);
  // Quit
  split->quit ();
  return 0;