MicrocircuitDB: Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279

Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]

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Model Type:	Axon;
Brain Region(s)/Organism:
Cell Type(s):	Leech S cell;
Channel(s):	I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	SNNAP;
Model Concept(s):
Implementer(s):	Crisp, Kevin [crisp at stolaf.edu];

Search NeuronDB for information about: I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;

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single.smu.exec

single.smu.hmn *

single.smu.out.head

singlezoom.ous.mnu

singlezoom.smu.exec

singlezoom.smu.hmn *

singlezoom.smu.ing

singlezoom.smu.out

singlezoom.smu.out.head

train.smu.hmn *

train.smu.out.head

This is the readme for the model associated with the paper:

Burrell BD, Crisp KM (2008) Serotonergic modulation of
afterhyperpolarization in a neuron that contributes to learning in the
leech. J Neurophysiol 99(2):605-616

This is the SNNAP code that was used by the paper authors.
Please contact Kevin Crisp crisp at stolaf.edu for more info.