The model used in this paper confirmed the experimental findings suggesting that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of
hippocampal CA1 pyramids, independently of alterations in synaptic activity.
The model predicts that the axonal Kv7 density could be 3-5 times that at the soma.
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 105:7869-74 [PubMed]