"We describe a new molecular mechanism of
dopamine-induced membrane protein modulation that
can tune neuronal oscillation frequency to attention related
gamma rhythm. This mechanism is based on
the unique ability of D4 dopamine receptors (D4R)
to carry out phospholipid methylation (PLM) that
may affect the kinetics of ion channels.
We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."
Kuznetsova AY, Deth RC (2008) A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. J Comput Neurosci 24:314-29 [PubMed]
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