Balance of excitation and inhibition (Carvalho and Buonomano 2009)

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Accession:125689
" ... Here, theoretical analyses reveal that excitatory synaptic strength controls the threshold of the neuronal input-output function, while inhibitory plasticity alters the threshold and gain. Experimentally, changes in the balance of excitation and inhibition in CA1 pyramidal neurons also altered their input-output function as predicted by the model. These results support the existence of two functional modes of plasticity that can be used to optimize information processing: threshold and gain plasticity."
Reference:
1 . Carvalho TP, Buonomano DV (2009) Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functions. Neuron 61:774-85 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Synaptic Integration;
Implementer(s):
/*--------------------------------------------------------------
    TEMPLATE FILE
        --------------------------------------------

        . ONE COMPARTMENT (soma)

        L = cell length, amount of current to fire a cell is directly proportional
                to the area of the cell.
--------------------------------------------------------------*/

begintemplate INPUTSoma            // create a new template object...
public soma //, dend
create soma //,dend
proc init() {
   soma {
	   Ra = 35			//*35        **1  ** = Carrie's						// Axial Resistivity
	   nseg = 1
	   diam = 10			//*10        **1                                // diameter in um: L and diam are used to calculate area
	   L = 10			//*10        **1                                    // length in um: relevant because g_pas is in mho/cm2
	   cm = 3			//*3         **0.1                                  // capacitance

	   insert ExIAF                         // includes
		   Thr_ExIAF = -45			//* -40		**-45	// -70
		   ePAS_ExIAF = -65			//*-60      **-65   // -70
		   gPAS_ExIAF = 0.0001		// time constant is 30 ms because cm = 3, 0.0001
		   eOFF_ExIAF = -60			//* -60               //e_pas
		   gAHPbar_ExIAF = 0.00007	//* 0.00007
	   insert NOISE
	   insert EPlasSom
	   insert EtoIPlasSom

  }
  print "<< INPUTSoma >>"
}
endtemplate INPUTSoma



begintemplate ExSoma            // create a new template object...
public soma, dend
create soma,dend
proc init() {
   soma {
	   Ra = 35                                              // Axial Resistivity
	   nseg = 1
	   diam = 10                                            // diameter in um: L and diam are used to calculate area
	   L = 10                                               // length in um: relevant because g_pas is in mho/cm2
	   cm = 3                                               // capacitance

	   insert ExIAF                         // includes
		   Thr_ExIAF = -40			//* -40			// -70
		   ePAS_ExIAF = -60         // -70  //Resting membrane potential
		   gPAS_ExIAF = 0.0001		// time constant is 30 ms because cm = 3, 0.0001
		   eOFF_ExIAF = -53			//* -60               //e_pas
		   gAHPbar_ExIAF = 0.00035	//* 0.00007
	   insert NOISE
	   insert EPlasSom
	   insert EtoIPlasSom

  }
  dend {
	  //*Ra = 35
      nseg = 10
      diam = 0.5
      L = 100
      insert pas
         e_pas = -60
         g_pas = 0.0001
         cm = 3
  }
  connect dend(0), soma(1)
  print "<< ExSoma >>"
}
endtemplate ExSoma





begintemplate InhSoma           // create a new template object...
public soma
create soma
proc init() {
   soma {
	Ra = 35                                   // geometry
	nseg = 1
	diam = 10
	L = 10                                       // such as surface = 1000 um2
	cm = 1.5                                    // 3

	insert InhIAF                     // includes
		Thr_InhIAF = -50			//* -45
		ePAS_InhIAF = -60         // -70
		gPAS_InhIAF = 0.0001      // time constant is 30 ms because cm = 3, 0.0001
		eOFF_InhIAF = -65         //e_pas
		gAHPbar_InhIAF = 0.00002	//*0.0002
		//tauAHP_InhIAF =	0.05			// IS NOT USED?? It was 0.05
	insert NOISE
	insert IPlasSom

  }
  print "<< InhSoma >>"
}
endtemplate InhSoma