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Shaping of action potentials by different types of BK channels (Jaffe et al., 2011)
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Dentate gyrus granule cells highly express the beta4 accessory subunit which confer BK channels with type II properties. The properties of heterologously-expressed BK channels (with and without the beta4 subunit) were used to construct channel models. These were then used to study how they affect single action potentials and trains of spikes in a model dentate gyrus granule cells (based on Aradi and Holmes, 1999).
Jaffe DB, Wang B, Brenner R (2011) Shaping of action potentials by type I and type II large-conductance Ca²+-activated K+ channels.
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Neuron or other electrically excitable cell;
Dentate gyrus granule GLU cell;
Jaffe, David B [david.jaffe at utsa.edu];
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Dentate gyrus granule GLU cell
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