Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

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Accession:144520
"Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work ..."
Reference:
1 . DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Cardiac ventricular cell;
Channel(s): I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s): HCN4;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
NEURON {
	GLOBAL Vi, Vcell, Vup, Vrel, S
}

PARAMETER {
	Vcell 	= 0.0157  	(mm3)  	: ok
	Vi 		= 0.014137	(mm3)	: Intracellular Volume
	Ve		= 0.00157	(mm3)	: ok
	
:	Vc 		= 	(cm3)		: cleft space
	Vup 	= 0.0007069 	(mm3)		: SR uptake Cptmt Vol
	Vrel 	= 0.0002827		(mm3)		: SR release Cptmt Vol

:	S = 0.6283			(um2)		: Surface pour Vi
	S = 0.063 			(cm2)
}