Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

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Accession:144520
"Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work ..."
Reference:
1 . DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Cardiac ventricular cell;
Channel(s): I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s): HCN4;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
TITLE Potassium ion accumulation wo cleft
COMMENT
	modified From DiFrancesco & Noble 1985 Phil Trans R Soc Lond 307:353-398 
    modified for Neuron by FE GANNIER
	francois.gannier@univ-tours.fr (University of TOURS)
ENDCOMMENT
INCLUDE "Unit.inc"
INCLUDE "Volume.inc"
NEURON {
	SUFFIX K_acc
	USEION k READ ki, ik, ko WRITE ki, ko
	RANGE ik, pf, kb
}

PARAMETER {
	ik 			(mA/cm2)
	kb = 4		(mM)
	
	pf = 0.7	(/s)
}

STATE {
	ki START 140	(mM)
	ko START 4		(mM)
}

LOCAL ViF, VeF
INITIAL {
	VERBATIM
		ki = _ion_ki;
		ko = _ion_ko;
	ENDVERBATIM
	VeF = (1e-3)*Ve*F/S
	ViF = (1e-3)*Vi*F/S
}

BREAKPOINT {
:	SOLVE state METHOD derivimplicit
	SOLVE state METHOD cnexp
}

: Rq  Ko = Kc
DERIVATIVE state { 
	
	ki' = -ik /ViF
	ko' = ik /VeF -(0.001)*pf*(ko - kb)
}