Region-specific atrophy in dendrites (Narayanan, Narayan, Chattarji, 2005)

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Accession:147756
...in this study, we develop an algorithm that uses statistics from precise morphometric analyses to systematically remodel neuronal reconstructions. We use the distribution function of the ratio of two normal distributed random variables to specify the probabilities of remodeling along various regions of the dendritic arborization. We then use these probabilities to drive an iterative algorithm for manipulating the dendritic tree in a region-specific manner. As a test, we apply this framework to a well characterized example of dendritic remodeling: stress-induced dendritic atrophy in hippocampal CA3 pyramidal cells. We show that our pruning algorithm is capable of eliciting atrophy that matches biological data from rodent models of chronic stress. <br>
Reference:
1 . Narayanan R, Narayan A, Chattarji S (2005) A probabilistic framework for region-specific remodeling of dendrites in three-dimensional neuronal reconstructions. Neural Comput 17:75-96 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Influence of Dendritic Geometry;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; 
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1007 4 12.063 159.028 0.45 0.4 1006
1008 4 12.914 162.513 3.7 0.4 1007
1009 4 15.667 164.681 5.45 0.4 1008
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1011 4 16.306 165.12 4.7 0.4 1010
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1013 4 19.059 174.044 4.7 0.4 1012
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1015 4 22.45 174.469 4.2 0.4 1014
1016 4 22.238 176.212 3.45 0.4 1015
1017 4 22.025 176.212 3.45 0.4 1016
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1021 4 25.403 185.575 -4.05 0.4 1020
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1036 4 40.871 209.063 -0.3 0.4 1033
1037 4 41.084 209.289 -0.3 0.4 1036
1038 4 38.956 214.502 10.95 0.4 1037
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1040 4 45.313 228.866 10.7 0.4 1039
1041 4 45.313 229.079 10.7 0.4 1040
1042 4 46.59 228.64 10.7 0.4 1041
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1045 4 1.689 162.513 0.7 0.72 1044
1046 4 1.689 162.726 0.7 0.72 1045
1047 4 2.115 166.862 0.7 0.72 1046
1048 4 1.277 177.741 0.7 0.72 1047
1049 4 1.277 177.741 0.725 0.72 1048
1050 4 1.277 178.606 0.7 0.72 1049
1051 4 1.277 178.606 0.725 0.24 1050
1052 4 -1.277 184.045 16.2 0.24 1051
1053 4 -3.817 184.471 14.7 0.24 1052
1054 4 -4.017 184.471 14.7 0.24 1053
1055 4 -7.621 190.562 6.95 0.24 1054
1056 4 -9.523 194.047 20.2 0.24 1055
1057 4 -12.489 196.228 18.45 0.24 1056
1058 4 -12.489 196.441 18.45 0.24 1057
1059 4 -14.404 196.228 21.95 0.24 1058
1060 4 -14.404 196.441 20.2 0.24 1059
1061 4 -18.846 204.926 9.7 0.24 1060
1062 4 -22.238 210.153 19.7 0.24 1061
1063 4 -27.318 218.625 19.7 0.24 1062
1064 4 -31.122 223.201 23.45 0.24 1063
1065 4 -36.415 238.868 25.4 0.24 1064
1066 4 -34.726 241.262 25.4 0.24 1065
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1068 4 -33.25 249.521 16.65 0.24 1067
1069 4 -30.909 251.703 16.65 0.24 1068
1070 4 -30.5544 257.689 16.8652 0.24 1069
1071 4 3.179 182.529 1.45 0.72 1050
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1075 4 8.685 200.365 -4.05 0.72 1074
1076 4 8.685 200.577 -4.05 0.72 1075
1077 4 8.259 204.926 -1.8 0.72 1076
1078 4 8.259 205.591 -3.05 0.72 1077
1079 4 8.259 205.591 -3.025 0.24 1078
1080 4 11.438 211.683 7.7 0.24 1079
1081 4 14.191 220.381 7.7 0.24 1080
1082 4 14.404 220.381 7.7 0.24 1081
1083 4 15.455 228.866 7.7 0.24 1082
1084 4 15.667 228.866 7.7 0.24 1083
1085 4 17.357 240.61 3.7 0.24 1084
1086 4 19.272 252.58 3.95 0.24 1085
1087 4 19.272 252.793 3.95 0.24 1086
1088 4 19.91 258.885 3.95 0.24 1087
1089 4 19.91 259.097 3.95 0.24 1088
1090 4 20.748 261.93 3.95 0.24 1089
1091 4 20.322 264.763 3.95 0.24 1090
1092 4 20.11 264.976 3.95 0.24 1091
1093 4 20.535 271.932 1.2 0.24 1092
1094 4 22.45 272.81 -0.8 0.24 1093
1095 4 21.5173 279.349 12.6672 0.24 1094
1096 4 9.111 207.108 -3.55 0.72 1078
1097 4 9.736 207.972 -6.3 0.72 1096
1098 4 9.736 207.972 -6.275 0.24 1097
1099 4 7.834 208.637 12.2 0.24 1098
1100 4 6.77 212.986 12.2 0.24 1099
1101 4 3.604 219.29 1.45 0.24 1100
1102 4 0.638 228.64 1.45 0.24 1101
1103 4 0.426 228.64 1.45 0.24 1102
1104 4 -4.229 240.823 1.45 0.24 1103
1105 4 -5.719 243.443 -2.3 0.24 1104
1106 4 -8.259 249.96 -2.3 0.24 1105
1107 4 -14.404 259.323 -2.55 0.24 1106
1108 4 -19.0567 266.58 5.79774 0.24 1107
1109 4 11.438 210.153 -2.8 0.56 1097
1110 4 12.489 212.108 -2.8 0.56 1109
1111 4 11.225 216.245 -2.8 0.56 1110
1112 4 12.702 217.987 -2.8 0.56 1111
1113 4 12.914 217.987 -2.8 0.56 1112
1114 4 15.455 221.033 -2.8 0.56 1113
1115 4 12.914 225.382 -3.05 0.56 1114
1116 4 12.914 225.595 -3.05 0.56 1115
1117 4 16.306 227.776 -3.05 0.56 1116
1118 4 16.306 227.989 -3.05 0.56 1117
1119 4 15.455 231.912 -4.8 0.56 1118
1120 4 16.731 237.126 -6.05 0.4 1119
1121 4 16.731 241.049 -9.8 0.4 1120
1122 4 18.208 248.444 -9.8 0.4 1121
1123 4 19.059 251.051 -9.8 0.4 1122
1124 4 20.961 251.929 -9.8 0.4 1123
1125 4 20.961 252.141 -9.8 0.4 1124
1126 4 23.714 259.762 -9.8 0.4 1125
1127 4 26.254 265.628 -9.8 0.4 1126
1128 4 26.041 268.899 -9.8 0.4 1127
1129 4 26.041 269.112 -9.8 0.4 1128
1130 4 31.973 274.326 -9.8 0.4 1129
1131 4 31.973 274.552 -9.8 0.4 1130
1132 4 32.186 280.856 -9.8 0.4 1131
1133 4 31.548 282.386 -17.3 0.4 1132
1134 4 36.203 286.296 -17.3 0.4 1133
1135 4 34.514 289.993 -17.3 0.4 1134
1136 4 34.301 289.993 -17.3 0.4 1135
1137 4 35.365 299.13 -17.3 0.4 1136
1138 4 35.152 299.13 -17.3 0.4 1137
1139 4 35.365 299.782 -17.3 0.4 1138
1140 4 35.365 299.782 -17.275 0.4 1139
1141 4 38.956 301.524 -21.8 0.4 1140
1142 4 40.658 303.479 -21.8 0.4 1141
1143 4 40.658 305.222 -21.8 0.4 1142
1144 4 44.05 306.751 -27.55 0.4 1143
1145 4 45.739 311.1 -27.55 0.4 1144
1146 4 45.739 311.313 -27.55 0.4 1145
1147 4 49.343 310.661 -27.3 0.4 1146
1148 4 50.181 313.494 -26.8 0.24 1147
1149 4 53.36 315.011 -26.8 0.24 1148
1150 4 56.326 319.147 -18.3 0.24 1149
1151 4 61.619 319.147 -17.8 0.24 1150
1152 4 61.832 322.193 -17.8 0.24 1151
1153 4 61.832 322.405 -17.8 0.24 1152
1154 4 66.274 322.844 -17.55 0.24 1153
1155 4 66.487 322.844 -17.55 0.24 1154
1156 4 69.027 327.845 -17.55 0.24 1155
1157 4 69.027 328.071 -17.55 0.24 1156
1158 4 69.24 332.194 -17.55 0.24 1157
1159 4 71.993 332.194 -17.55 0.24 1158
1160 4 71.78 332.194 -17.55 0.24 1159
1161 4 73.27 338.286 -17.55 0.24 1160
1162 4 73.27 338.512 -17.55 0.24 1161
1163 4 76.648 339.376 -17.3 0.24 1162
1164 4 78.776 345.042 -17.3 0.24 1163
1165 4 78.563 345.042 -17.3 0.24 1164
1166 4 77.074 350.043 -17.3 0.24 1165
1167 4 84.907 356.56 -17.3 0.24 1166
1168 4 85.546 359.393 -5.8 0.24 1167
1169 4 85.333 359.393 -5.8 0.24 1168
1170 4 87.448 359.832 -5.8 0.24 1169
1171 4 89.562 362.226 -5.8 0.24 1170
1172 4 92.954 362.651 -5.8 0.24 1171
1173 4 96.132 368.53 -5.8 0.24 1172
1174 4 94.856 371.137 0.45 0.24 1173
1175 4 94.656 371.137 0.45 0.24 1174
1176 4 96.132 374.408 0.45 0.24 1175
1177 4 96.132 374.621 0.45 0.24 1176
1178 4 94.23 379.409 2.7 0.24 1177
1179 4 96.558 383.758 -14.55 0.24 1178
1180 4 96.558 383.971 -14.55 0.24 1179
1181 4 94.856 390.727 -14.3 0.24 1180
1182 4 94.656 390.727 -14.3 0.24 1181
1183 4 95.92 393.334 -14.05 0.24 1182
1184 4 95.707 393.108 -14.05 0.24 1183
1185 4 95.494 393.547 -14.05 0.24 1184
1186 4 94.018 398.987 -14.3 0.24 1185
1187 4 91.69 405.078 -14.3 0.24 1186
1188 4 89.15 407.033 -12.05 0.24 1187
1189 4 90.413 417.7 -2.55 0.24 1188
1190 4 85.12 427.05 -11.05 0.24 1189
1191 4 82.793 434.671 -11.05 0.24 1190
1192 4 81.516 438.794 -11.05 0.24 1191
1193 4 81.167 440.167 -12.4613 0.24 1192
1194 4 35.365 300.008 -17.3 0.4 1139
1195 4 33.662 303.479 -26.8 0.4 1194
1196 4 33.662 303.706 -26.8 0.4 1195
1197 4 35.152 308.919 -26.8 0.4 1196
1198 4 35.152 309.358 -26.8 0.4 1197
1199 4 33.875 315.888 -26.8 0.4 1198
1200 4 33.25 322.631 -36.55 0.4 1199
1201 4 33.25 322.844 -36.55 0.4 1200
1202 4 35.365 325.238 -36.55 0.4 1201
1203 4 31.122 342.209 -36.55 0.4 1202
1204 4 31.973 349.165 -36.55 0.4 1203
1205 4 27.318 362.226 -37.55 0.4 1204
1206 4 26.467 364.832 -37.55 0.4 1205
1207 4 25.829 365.697 -37.8 0.4 1206
1208 4 25.204 371.137 -37.8 0.24 1207
1209 4 24.991 376.151 -38.05 0.24 1208
1210 4 24.778 376.363 -38.05 0.24 1209
1211 4 22.663 381.803 -38.05 0.24 1210
1212 4 20.961 385.288 -38.3 0.24 1211
1213 4 20.961 385.501 -38.3 0.24 1212
1214 4 22.025 392.031 -38.3 0.24 1213
1215 4 20.748 393.773 -41.05 0.24 1214
1216 4 20.322 398.774 -43.05 0.24 1215
1217 4 20.322 398.987 -43.05 0.24 1216
1218 4 20.535 407.259 -46.55 0.24 1217
1219 4 20.535 407.472 -46.55 0.24 1218
1220 4 19.272 409.866 -47.3 0.24 1219
1221 4 19.91 412.699 -47.3 0.24 1220
1222 4 19.91 412.912 -47.3 0.24 1221
1223 4 18.421 415.958 -47.3 0.24 1222
1224 4 19.697 419.216 -50.3 0.24 1223
1225 4 15.88 422.488 -50.3 0.24 1224
1226 4 15.029 434.232 -54.55 0.24 1225
1227 4 12.489 442.93 -40.55 0.24 1226
1228 4 10.161 446.415 -40.55 0.24 1227
1229 4 9.948 446.627 -40.55 0.24 1228
1230 4 9.523 448.809 -40.55 0.24 1229
1231 4 7.621 453.37 -38.55 0.24 1230
1232 4 7.834 455.113 -38.8 0.24 1231
1233 4 7.834 455.339 -38.8 0.24 1232
1234 4 6.57 457.507 -38.8 0.24 1233
1235 4 6.357 457.733 -38.8 0.24 1234
1236 4 7.195 459.462 -39.55 0.24 1235
1237 4 5.932 462.082 -31.05 0.24 1236
1238 4 5.506 463.598 -30.05 0.24 1237
1239 4 6.983 465.128 -43.55 0.24 1238
1240 4 5.719 469.038 -44.05 0.24 1239
1241 4 5.506 469.477 -44.05 0.24 1240
1242 4 6.76987 476.362 -44.05 0.24 1241
1243 4 25.829 365.697 -37.775 0.24 1207
1244 4 22.863 370.059 -23.55 0.24 1243
1245 4 17.569 376.802 -24.55 0.24 1244
1246 4 17.357 376.802 -24.55 0.24 1245
1247 4 17.569 378.97 -24.55 0.24 1246
1248 4 15.455 379.622 -24.55 0.24 1247
1249 4 15.242 379.622 -24.55 0.24 1248
1250 4 14.191 381.803 -24.55 0.24 1249
1251 4 12.914 382.668 -24.8 0.24 1250
1252 4 12.914 382.894 -24.8 0.24 1251
1253 4 13.127 387.243 -24.8 0.24 1252
1254 4 12.914 387.456 -24.8 0.24 1253
1255 4 12.914 387.682 -25.8 0.24 1254
1256 4 10.587 388.759 -11.05 0.24 1255
1257 4 10.374 388.759 -11.05 0.24 1256
1258 4 10.161 391.153 -11.05 0.24 1257
1259 4 9.736 391.592 -11.05 0.24 1258
1260 4 7.621 394.425 -11.05 0.24 1259
1261 4 7.621 394.638 -11.05 0.24 1260
1262 4 8.685 395.941 -11.05 0.24 1261
1263 4 8.259 397.471 -11.05 0.24 1262
1264 4 5.719 401.82 -6.3 0.24 1263
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1266 4 3.391 405.517 -6.3 0.24 1265
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1401 3 38.397 -49.676 -19.5 0.24 1400
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1404 3 49.622 -53.373 -25.25 0.24 1403
1405 3 54.888 -56.2487 -25.25 0.24 1404
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1419 3 68.256 -81.436 -11.75 0.56 1418
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1424 3 90.906 -92.089 -23.5 0.4 1423
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1439 3 123.517 -107.105 -11.5 0.24 1438
1440 3 125.432 -106.666 -11.5 0.24 1439
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1472 3 27.172 -55.767 -8 0.56 1471
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1474 3 27.81 -64.252 -3.25 0.56 1473
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1479 3 29.712 -76.435 -5.975 0.4 1478
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1494 3 70.796 -156.927 -2.25 0.24 1493
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1497 3 69.945 -159.746 7.5 0.24 1496
1498 3 73.336 -162.792 -5 0.24 1497
1499 3 74.5175 -165.539 -4.7573 0.24 1498
1500 3 29.712 -76.209 -6 0.56 1478
1501 3 30.989 -79.694 -6 0.4 1500
1502 3 31.202 -80.345 -6 0.4 1501
1503 3 32.053 -82.088 -3.5 0.4 1502
1504 3 32.053 -81.875 -3.5 0.4 1503
1505 3 30.351 -85.572 -4.5 0.4 1504
1506 3 30.776 -87.966 2.5 0.4 1505
1507 3 31.415 -91.664 -4.5 0.4 1506
1508 3 31.415 -91.438 -4.5 0.4 1507
1509 3 29.3 -93.406 5 0.4 1508
1510 3 28.874 -99.71 1.75 0.4 1509
1511 3 26.746 -102.317 1.75 0.4 1510
1512 3 26.746 -102.104 1.75 0.4 1511
1513 3 27.385 -108.634 1.5 0.4 1512
1514 3 27.81 -113.196 1.5 0.4 1513
1515 3 29.3 -116.029 1.25 0.4 1514
1516 3 28.662 -125.818 0.5 0.4 1515
1517 3 27.385 -128.638 0.5 0.4 1516
1518 3 28.449 -131.909 0.5 0.4 1517
1519 3 25.696 -135.82 0.5 0.4 1518
1520 3 25.057 -139.091 1 0.4 1519
1521 3 26.334 -143.002 1.25 0.4 1520
1522 3 26.334 -143.214 1.25 0.4 1521
1523 3 24.632 -146.699 1.5 0.4 1522
1524 3 24.007 -154.094 1.25 0.4 1523
1525 3 24.007 -162.792 1.5 0.4 1524
1526 3 24.419 -172.155 11.75 0.4 1525
1527 3 26.547 -180.641 11 0.4 1526
1528 3 26.334 -180.641 11 0.4 1527
1529 3 27.81 -191.081 10.75 0.4 1528
1530 3 29.712 -196.734 10.75 0.4 1529
1531 3 29.4681 -200.727 10.75 0.4 1530
1532 3 17.862 -39.009 -13.475 0.56 1393
1533 3 22.517 -43.145 -10.25 0.56 1532
1534 3 27.81 -44.675 -10.25 0.56 1533
1535 3 33.742 -46.843 -24 0.4 1534
1536 3 37.759 -46.191 -24 0.4 1535
1537 3 39.674 -46.63 -24.5 0.4 1536
1538 3 37.546 -50.766 -27.5 0.4 1537
1539 3 42.839 -52.07 -27.5 0.4 1538
1540 3 48.771 -57.283 -29 0.4 1539
1541 3 55.129 -58.813 -29 0.4 1540
1542 3 54.916 -58.813 -28.75 0.4 1541
1543 3 57.789 -61.526 -25 0.56 1542
1544 3 62.71 -62.204 -4.5 0.56 1543
1545 3 65.436 -61.818 -26.75 0.56 1544
1546 3 65.489 -62.031 -19.5 0.56 1545
1547 3 69.399 -67.843 -30.5 0.56 1546
1548 3 78.098 -69.918 -30 0.56 1547
1549 3 78.35 -70.078 -29.25 0.56 1548
1550 3 78.35 -70.078 -29.225 0.4 1549
1551 3 80.146 -75.065 -19.75 0.4 1550
1552 3 86.277 -77.26 -19.75 0.4 1551
1553 3 86.237 -77.047 -19.75 0.4 1552
1554 3 89.31 -80.146 -43.5 0.4 1553
1555 3 94.39 -83.471 -47.25 0.4 1554
1556 3 94.35 -83.258 -47.25 0.4 1555
1557 3 101.213 -87.74 -26.5 0.4 1556
1558 3 101 -87.793 -26.5 0.4 1557
1559 3 106.546 -91.238 -59.25 0.4 1558
1560 3 117.399 -97.05 -44.25 0.4 1559
1561 3 125.791 -101.639 -53 0.4 1560
1562 3 126.004 -101.599 -53 0.4 1561
1563 3 131.537 -103.035 -38.25 0.4 1562
1564 3 133.186 -105.562 -65 0.4 1563
1565 3 138.16 -106.453 -74.5 0.4 1564
1566 3 144.132 -111.813 -77.5 0.4 1565
1567 3 153.229 -120.471 -78 0.4 1566
1568 3 161.688 -127.281 -78.25 0.4 1567
1569 3 169.854 -133.705 -77.75 0.4 1568
1570 3 169.642 -133.745 -77.75 0.4 1569
1571 3 177.635 -138.426 -83 0.4 1570
1572 3 187.051 -143.68 -89.25 0.4 1571
1573 3 191.33 -144.224 -97.1492 0.4 1572
1574 3 78.151 -70.131 -29.25 0.56 1549
1575 3 77.526 -73.163 -34 0.4 1574
1576 3 80.665 -78.483 -34 0.4 1575
1577 3 85.253 -80.571 -41 0.4 1576
1578 3 86.41 -84.774 -41 0.4 1577
1579 3 86.157 -84.601 -41 0.4 1578
1580 3 90.161 -85.054 -41 0.4 1579
1581 3 91.544 -88.312 -44.5 0.4 1580
1582 3 95.627 -87.168 -44.5 0.4 1581
1583 3 98.965 -87.541 -58.75 0.4 1582
1584 3 98.753 -87.581 -58.75 0.4 1583
1585 3 98.5 -90.32 -60.25 0.4 1584
1586 3 98.247 -90.147 -60.25 0.4 1585
1587 3 102.25 -90.6 -60.25 0.4 1586
1588 3 108.422 -90.999 -66.5 0.4 1587
1589 3 114.34 -93.246 -71 0.4 1588
1590 3 119.926 -94.896 -76.25 0.4 1589
1591 3 130.167 -99.963 -78.25 0.24 1590
1592 3 139.012 -105.562 -79.25 0.24 1591
1593 3 147.218 -109.299 -94.25 0.24 1592
1594 3 154.28 -111.733 -97 0.24 1593
1595 3 155.544 -115.457 -99.25 0.24 1594
1596 3 155.344 -115.511 -99.25 0.24 1595
1597 3 161.249 -115.75 -105 0.24 1596
1598 3 163.417 -120.604 -105.5 0.24 1597
1599 3 166.995 -122.041 -104 0.24 1598
1600 3 166.955 -121.828 -104 0.24 1599
1601 3 169.256 -125.326 -103.5 0.24 1600
1602 3 174.596 -127.249 -107.597 0.24 1601
1603 3 65.489 -62.031 -19.475 0.4 1546
1604 3 72.857 -63.547 -18 0.4 1603
1605 3 75.89 -57.735 -18 0.4 1604
1606 3 75.85 -57.523 -18 0.4 1605
1607 3 80.039 -58.826 -18.25 0.4 1606
1608 3 80.252 -58.773 -18.25 0.4 1607
1609 3 81.941 -53.719 -18.5 0.4 1608
1610 3 81.888 -53.506 -18.5 0.4 1609
1611 3 87.354 -55.621 -57 0.4 1610
1612 3 89.842 -52.176 -62 0.4 1611
1613 3 89.788 -51.963 -62.5 0.4 1612
1614 3 89.589 -52.003 -62.5 0.4 1613
1615 1 -1.476 -10.002 1 5.01 1383
1616 1 -1.689 -11.744 1 4.69 1615
1617 1 -1.064 -13.712 1 3.58 1616
1618 1 -1.064 -14.79 1 2.63 1617
1619 1 -0.638 -15.88 1 1.83 1618
1620 1 -0.638 -16.532 1 1.83 1619