Modeling maintenance of Long-Term Potentiation in clustered synapses (Smolen 2015)


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Accession:185875
" ... Here a model is developed that connects ongoing, competing processes of synaptic growth and weakening to stochastic processes of receptor insertion and removal in dendritic spines. The model simulates long-term (>1 yr) persistence of groups of strong synapses. A unimodal weight distribution results. For stability of this distribution it proved essential to incorporate resource competition between synapses organized into small clusters. ..."
Reference:
1 . Smolen P (2015) Modeling maintenance of long-term potentiation in clustered synapses: long-term memory without bistability. Neural Plast 2015:185410 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Java (web link to model);
Model Concept(s): Long-term Synaptic Plasticity;
Implementer(s): Smolen, Paul [paul.d.smolen at uth.tmc.edu];
(located via links below)