MicrocircuitDB: Glutamate-evoked Ca2+ oscillations in single astrocytes (De Pitta et al. 2009) (Manninen et al 2017)

Glutamate-evoked Ca2+ oscillations in single astrocytes (De Pitta et al. 2009) (Manninen et al 2017)

Download zip file
Help downloading and running models

Model Information
Model File

Accession:223269

We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by De Pitta et al. (2009) was one of them. We implemented and ran the model by De Pitta et al. (2009) using Jupyter Notebook. Model code produces results of Figure 1 and Figures 3-5 in Manninen, Havela, Linne (2017).
Reference:
1 . De Pittà M, Goldberg M, Volman V, Berry H, Ben-Jacob E (2009) Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes. J Biol Phys 35:383-411 [PubMed]
2 . Manninen T, Havela R, Linne ML (2017) Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform.
3 . De Pittà M, Goldberg M, Volman V, Berry H, Ben-Jacob E (2010) Erratum to: Glutamate regulation of calcium and IP(3) oscillating and pulsating dynamics in astrocytes. J Biol Phys 36:221 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Glia;
Brain Region(s)/Organism:	Generic;
Cell Type(s):	Astrocyte;
Channel(s):
Gap Junctions:
Receptor(s):	IP3;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	Python;
Model Concept(s):	Calcium dynamics; Oscillations; Signaling pathways;
Implementer(s):	Manninen, Tiina [tiina.h.manninen at gmail.com];

Search NeuronDB for information about: IP3; Glutamate;

File not selected

<- Select file from this column.