" ...Here, we
demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an
efficacious model of reward-based navigation. Specifically, our experimental data in mouse
hippocampal slices show that acetylcholine biases STDP toward synaptic depression, whilst
subsequent application of dopamine converts this depression into potentiation. Incorporating this
bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational
model yields effective navigation toward changing reward locations, as in natural foraging
behavior. ..."
Reference:
1 .
Brzosko Z, Zannone S, Schultz W, Clopath C, Paulsen O (2017) Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation. Elife [PubMed]
|