MicrocircuitDB: PKMZ synthesis and AMPAR regulation in late long-term synaptic potentiation (Helfer & Shultz 2018)

PKMZ synthesis and AMPAR regulation in late long-term synaptic potentiation (Helfer & Shultz 2018)

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Accession:239541

Stochastic simulation of a set of molecular reactions that implement late long-term potentiation (L-LTP). The model is able to account for a wide range of empirical results, including induction and maintenance of late-phase LTP, cellular memory reconsolidation and the effects of different pharmaceutical interventions.
Reference:
1 . Helfer P, Shultz TR (2018) Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking. PLoS Comput Biol 14:e1006147 [PubMed]
2 . Helfer P, Shultz TR (2018) Coupled feedback loops maintain synaptic long-term potentiation: A computational model arXiv

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Model Information (Click on a link to find other models with that property)

Model Type:	Synapse; Molecular Network;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	C or C++ program;
Model Concept(s):	Long-term Synaptic Plasticity; Synaptic Plasticity;
Implementer(s):	Helfer, Peter [peter.helfer at mail.mcgill.ca];

Search NeuronDB for information about: AMPA; Glutamate;

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