Retinal ganglion cells responses and activity (Tsai et al 2012, Guo et al 2016)

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Accession:260653
From the abstracts: "Retinal ganglion cells (RGCs), which survive in large numbers following neurodegenerative diseases, could be stimulated with extracellular electric pulses to elicit artificial percepts. How do the RGCs respond to electrical stimulation at the sub-cellular level under different stimulus configurations, and how does this influence the whole-cell response? At the population level, why have experiments yielded conflicting evidence regarding the extent of passing axon activation? We addressed these questions through simulations of morphologically and biophysically detailed computational RGC models on high performance computing clusters. We conducted the analyses on both large-field RGCs and small-field midget RGCs. ...", "... In this study, an existing RGC ionic model was extended by including a hyperpolarization activated non-selective cationic current as well as a T-type calcium current identified in recent experimental findings. Biophysically-defined model parameters were simultaneously optimized against multiple experimental recordings from ON and OFF RGCs. ...
Reference:
1 . Guo T, Tsai D, Morley JW, Suaning GJ, Kameneva T, Lovell NH, Dokos S (2016) Electrical activity of ON and OFF retinal ganglion cells: a modelling study. J Neural Eng 13:025005 [PubMed]
2 . Tsai D, Chen S, Protti DA, Morley JW, Suaning GJ, Lovell NH (2012) Responses of retinal ganglion cells to extracellular electrical stimulation, from single cell to population: model-based analysis. PLoS One 7:e53357 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina ganglion GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Activity Patterns; Development;
Implementer(s): Tsai, David [d.tsai at unsw.edu.au];
Search NeuronDB for information about:  Retina ganglion GLU cell; 
    -- Last updated Mon 27 Feb 2012 00:36:15 EST

USAGE
    For standard GUI run mode
        make clean && make
        nrngui rgc-ctt3219m.hoc
    
    To run in MPI-compatible batch mode
        make clean && make mpi
        {time mpiexec -np 4 nrniv-mpi -mpi -nogui ./jobs/X.hoc} 2>&1 | tee -a out
            or
        {time mpirun -np 4 nrniv-mpi -mpi -nogui ./jobs/X.hoc} 2>&1 | tee -a out


FILE SUMMARY
    jobs/                    Script files for automated runs
    output/                  Computation output goes here
    regression/              Regression tests for RGCs
    scripts/                 Matlab scripts for data processing

    *.ses                    Session files for setting up the UI
    *.mod                    Model mechanism implementation files

    init-rgc-*.hoc           Initialization files for running RGCs 

    rgc-121203.hoc           Mice RGC with morphology by Kong05 (Masland)
    rgc-121821.hoc           Mice RGC with morphology by Kong05 (Masland)
    rgc-ctt3219m.asc         Salamander simple RGC morphology from Sheasby paper
    rgc-ctt3219m.hoc         Model spec for above
    rgc-lws9287r.asc         Salamander complex RGC morphology from sheasby paper
    rgc-lws9287r.hoc         Model spec for above

    autoThresholdMap.hoc     Computes threshold map automatically, supports MPI
    autoTileThresholdMap.hoc Computes threshold map automatically, supports MPI
    global.hoc               Cell-invariant global definitions
    gui.hoc                  Graphical user interface elements
    instr.hoc                Instrumentations for cells
    interpxyz.hoc            Extracellular stimulation supoort
    stim.hoc                 Extracellular stimulation definition
    util.hoc                 General utility functions