Syn Plasticity Regulation + Information Processing in Neuron-Astrocyte Networks (Vuillaume et al 21)

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"... we consider a model of astrocyte-regulated synapses to investigate this hypothesis at the level of layered networks of interacting neurons and astrocytes. Our simulations hint that gliotransmission sustains the transfer function across layers, although it decorrelates the neuronal activity from the signal pattern..."
1 . Vuillaume R, Lorenzo J, Binczak S, Jacquir S (2021) A Computational Study on Synaptic Plasticity Regulation and Information Processing in Neuron-Astrocyte Networks Neural Computation 33(7):1970-1992 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Astrocyte;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Transmitter(s): Gaba;
Simulation Environment: Brian 2;
Model Concept(s): Dynamic extracellular concentrations; Calcium dynamics;
Implementer(s): Vuillaume, Roman;
Search NeuronDB for information about:  AMPA; NMDA; Gaba;
This code is provided as support material for the study:

A computational study on the regulation of synaptic plasticity and synaptic information processing in neuron-astrocyte networks.

The code has been written by R. Vuillaume, based on M. Stimberg study: Modeling neuron-glia interactions with the Brian 2 simulator (

The code takes several arguments:

-a 0 (fixed)
-b x (with x between 0 and 10, it fixes the switching frequency of the input signal)
-c y (with any integer, it fixes the random seed for reproducibility across condition)