Human L5 Cortical Circuit (Guet-McCreight)

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Accession:267587
We used L5 Pyr neuron models fit to electrophysiology data from younger and older individuals to simulate detailed human layer 5 microcircuits. These circuits also included detailed parvalbumin+ (PV), somatostatin+ (SST), and vasoactivate intestinal polypeptide+ (VIP) inhibitory interneuron models.
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Human; Neocortex;
Cell Type(s): Neocortex U1 interneuron basket PV GABA cell; Neocortex U1 interneuron bipolar VIP/CR GABA cell; Neocortex layer 5 pyramidal cell;
Channel(s): I h; I Na,t; I Na,p; I M; IK Skca; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON; LFPy;
Model Concept(s): Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB for information about:  Neocortex U1 interneuron basket PV GABA cell; Neocortex U1 interneuron bipolar VIP/CR GABA cell; AMPA; NMDA; Gaba; I Na,p; I Na,t; I K; I M; I h; IK Skca; Gaba; Glutamate;