Pyramidal Neuron Deep: attenuation in dendrites (Stuart, Spruston 1998)

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Accession:3677
Stuart, G. and Spruston, N. Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. Journal of Neuroscience 18:3501-3510, 1998.
Reference:
1 . Stuart G, Spruston N (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci 18:3501-10 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting;
Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I h;
proc init_params() {
	strdef somareadfile, dendreadfile
	somareadfile="ri18scs.asc" /* "ri18scon.asc" */
	dendreadfile="ri18dcs.asc" /* "ri18dcon.asc" */
	somav="dend1[21].v(0.5)"     /* somatic recording site */
	dendv="dend1[183].v(0.01)"   /* dendritic recording site */
	basalv="dend1[824].v(0.99)"  /* dendritic recording site */
	tuftv="dend1[386].v(0.99)"   /* dendritic recording site */
	/* initialize user-defined membrane parameters */
	celsius = 35
	global_ra=150    /* internal resistivity in ohm-cm */
	     /* global_ra=151  adjusted for 2% sag simulation */
	     /* global_ra=130  /* adjusted for nu Rm simulation */
	Cm=1.0           /* specific membrane capacitance in uF/cm^2 */
	Rm=23375         /* specific membrane resistivity in ohm-cm^2 */
  	    /* Rm=13714     adjusted for low Rm simulation */
   	    /* Rm=26750     /* adjusted for sag simulation */
  	    /* Rm=26750     /* adjusted for nonuniform Rm simulation */
	Vleak=-67        /* reversal of the leak potential in mV */
	qblock=0         /* fraction of q current blocked by Cs */
	nablock=1        /* fraction of na current blocked by TTX */
	kblock=1         /* fraction of k current blocked */
	spinescale=2.0   /* scale total area to account for spines */
	areascale=1.30   /* scale total area by an additional factor */
	    /* areascale=1.44   adjusted for 2% sag simulation */
	target=53.6      /* input resistance target in CsCl */
	    /* target=35.5   adjusted for low Rm simulation */
	/* parameter changes for low Rm simulation */
	/* global_ra = 98.5 */
	/* Rm = 32000 */
	/* areascale = 1.2946 */
	rmscale = 1241	/* for nonuniform rm simulations */
}

init_params()