Pyramidal Neuron Deep: attenuation in dendrites (Stuart, Spruston 1998)

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Accession:3677
Stuart, G. and Spruston, N. Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. Journal of Neuroscience 18:3501-3510, 1998.
Reference:
1 . Stuart G, Spruston N (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci 18:3501-10 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting;
Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I h;
/* access dend1[21]   -- somatic recording site at 0.5    */
/* access dend1[183] -- dendritic recording site at 0.01 */

graphicson = 1    /* 1 graphics on, -1 graphics off */
writeout = 0      /* equals 1 if output should be written to a file */
makeplot = 0

//xopen("$(NEURONHOME)/lib/hoc/noload.hoc")
//xopen("mystdrun.hoc")
xopen("replace.hoc")
xopen("ri18geo.hoc")
xopen("ri18init.hoc")
xopen("ri18func.hoc")
nrnmainmenu()
nrncontrolmenu()

tstop=400	/* total duration of simulation */
long=1		/* greater than zero for long pulse */
short=0		/* greater than zero for short pulse */
both=0		/* greater than zero for short + long pulse */
syn=0		/* greater than zero for synaptic simulation */
ipass=2		/* =1 for uniform Rm, =2 for nonuniform Rm */
initq=2		/* =1 for uniform Ih, =2 for nonuniform Ih */

init_params()

if (syn<1) {
	read_expt_data()
}

insert_pass()			/* insert passive membrane */

if (ipass<1) {
	init_pass1(Cm)		/* initialize uniform passive membrane */
}
if (ipass>0) {
	init_pass2(Cm)		/* initialize nonuniform passive membrane */
}
if (qblock<1) {
  insertq()				/* insert q conductance */
  if (initq<2) {
    initq1(qten_qq/10)	/* initialize uniform q conductance */
  }
  if (initq>1) {
    initq2(qten_qq)		/* initialize nonuniform q conductance */
  }
}		

/* initnakhh()	*/		/* initialize active HH Na/K conductances */

if (graphicson>0) {
  newPlotV(-80,-60)
}

init()			/* initialize v and active states */

if (syn<1) {
	somarawvec.play(&somarawv,vecdt)
	dendrawvec.play(&dendrawv,vecdt)
	somarawvec.play_remove()
	dendrawvec.play_remove()
}
somarawvec.add(somaticv())
dendrawvec.add(dendriticv())
if (syn<1) {
	somarawvec.play(&somarawv,vecdt)
	dendrawvec.play(&dendrawv,vecdt)
}

/* send stim, delay, duration, tmax, dt */
if (long>0) {
	tstop=400
	somastep_cc(-0.05, 51.3, 201.4, tstop, 0.5)
/*	dendstep_cc(-0.06, 51.3, 201.4, tstop, 0.2) */
	graphItem.size(0,tstop,-68,-62)
}
if (short>0) {
	tstop=100
	somastep_cc(-2.0, 5.06, 1.008, 100, 0.1)
	graphItem.size(0,tstop,-79,-76)
}

if (syn>0) {
	tstop=100
	print "simulating synaptics"
	syn_cc2(0.5, 0.001, 0.2, 2, 0, 5, tstop, 0.1)
	/* send location, gmax (mS), tau0, tau1, erev, delay, tmax, dt */
	graphItem.size(0,tstop,somaticv()-0.5,dendriticv()+maxvdend+0.5)
}

if (writeout>0) {
	somaoutname = "ri18syns6.sim"
	dendoutname = "ri18synd6.sim"
	write_data()
}

if (syn<1) {
	rn=abs(ssvsoma/elecstim.amp)
	printf("Input resistance = %f Mohms\n",rn)
}
printf("Max. voltage change at somatic electrode = %f mV\n\n",maxvsoma)
printf("Max. voltage change at dendritic electrode = %f mV\n\n",maxvdend)
printf("Attenuation = %f \n\n",maxvdend/maxvsoma)
printf("MS error soma = %f \n\n",mserrsoma)
printf("MS error dend = %f \n\n",mserrdend)
printf("sag ratio = %f \n", ssvsoma/maxvsoma)
wopen()

print"DONE\n"