Febrile seizure-induced modifications to Ih (Chen et al 2001)

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Accession:8284
Modeling and experiments in the paper Chen K,Aradi I, Thom N,Eghbal-Ahmadi M, Baram TZ, and Soltesz I (2001) support the hypothesis that modified Ih currents strongly influence inhibitory inputs in CA1 cells and that the depolarizing shift in Ih activation plays a primary role in this process. Please see the paper for details. Some modeling details are available at http://www.ucihs.uci.edu/anatomy/soltesz/supp.htm Correspondance should be addressed to isoltesz@uci.edu (modeling was done by Ildiko Aradi, iaradi@uci.edu)
Reference:
1 . Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I (2001) Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 7:331-7 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Action Potentials; Epilepsy; Rebound firing;
Implementer(s): Aradi, Ildiko [IAradi at uci.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I K; I h;
COMMENT
Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I: Persistently modified
h-channels after complex febrile seizures convert the seizure-induced enhancement of
inhibition to hyperexcitability. Nature Medicine, 7(3) pp. 331-337, 2001.
(modeling by Ildiko Aradi, iaradi@uci.edu)
synaptic current initiation
ENDCOMMENT
					       
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS ppsyn
	RANGE on, tau1, tau2, gsbar, es, is, deadtime
	NONSPECIFIC_CURRENT is
}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(umho) = (micromho)
}

PARAMETER {
	tau1 (ms)
	tau2 (ms)
	gsbar 	(umho)
	es	(mV)
	v	(mV)
	on (ms) 
}

PARAMETER {
	deadtime (ms)
}

ASSIGNED {
	is (nA)
	gs (umho)
	}

BREAKPOINT {
	SOLVE getonset
	gs=gsbar * on
	is = gs*(v-es)
}


PROCEDURE getonset() {
	if ( t < deadtime) {
		on = 0
	}
	if ( t> deadtime) {
	on = (exp(-(t-deadtime)/tau2)-exp(-(t-deadtime)/tau1))	}
				}