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Spiking neuron model of the basal ganglia (Humphries et al 2006)
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A spiking neuron model of the basal ganglia (BG) circuit (striatum, STN, GP, SNr). Includes: parallel anatomical channels; tonic dopamine; dopamine receptors in striatum, STN, and GP; burst-firing in STN; GABAa, AMPA, and NMDA currents; effects of synaptic location. Model demonstrates selection and switching of input signals. Replicates experimental data on changes in slow-wave (<1 Hz) and gamma-band oscillations within BG nuclei following lesions and pharmacological manipulations.
Humphries MD, Stewart RD, Gurney KN (2006) A physiologically plausible model of action selection and oscillatory activity in the basal ganglia.
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Neostriatum medium spiny direct pathway GABA cell;
Subthalamus nucleus projection neuron;
Globus pallidus neuron;
Abstract integrate-and-fire leaky neuron;
Action Selection/Decision Making;
Humphries, Mark D [m.d.humphries at shef.ac.uk];
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Neostriatum medium spiny direct pathway GABA cell
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