Periodicity in Na channel properties alters model neuron excitability (Majumdar and Sikdar 2007)

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"... We have shown earlier that the duration and amplitude of a prolonged depolarization alter all the steady state and kinetic parameters of rNav1.2a voltage gated Na channel in a pseudo-oscillatory fashion. In the present study, we show that the Hodgkin–Huxley voltage and time dependent rate constants of activation (am and bm) and fast inactivation (ah and bh), obtained from the analyses of Na currents and steady state activation and inactivation plots, following application of prepulses in both slow (1–100 s) and fast (100–1000 ms) ranges, vary with the duration of a prepulse in a pseudo-oscillatory manner. ..."
1 . Majumdar S, Sikdar SK (2007) Periodicity in Na+ channel properties alters excitability of a model neuron Biochem Biophys Res Commun.
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Simulation Environment: GENESIS;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Search NeuronDB for information about:  I Na,t; I K;
// initialize the random # generator

float PI = 3.14159

// channel equilibrium potentials	V
// resting membrane potential

float EREST = -0.080
float ENa = 0.125 + EREST
float EK = -0.012 + EREST

// leakage potential
float Eleak = 0.0106 + EREST

// cell dimensions (meters)

float soma_l = 30e-6 // cylinder equivalent to 30 micron sphere
float soma_d = 30e-6
float SOMA_A = soma_l*PI*soma_d*1.0  //sq. meter 

// peak channel conductance	S/synapse
float GNa = 80e-12
float GK = 40e-12