Dentate gyrus granule cell: subthreshold signal processing (Schmidt-Hieber et al. 2007)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:95960
Detailed compartmental cable models of 8 hippocampal granule cells of adult mice were obtained from dual patch-clamp whole-cell recordings and subsequent 3D reconstructions. This code allows to reproduce figures 6-8 from the paper.
Reference:
1 . Schmidt-Hieber C, Jonas P, Bischofberger J (2007) Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells. J Neurosci 27:8430-41 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; Glutamate;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting; Influence of Dendritic Geometry; Synaptic Integration;
Implementer(s): Schmidt-Hieber, Christoph [c.schmidt-hieber at ucl.ac.uk];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; AMPA; Glutamate; Glutamate; 
// ----------------------------------------------------------------------------
// spine.hoc
// Create a spine with a terminal expansion
// and a synapse on its tip, as described by Hama et al., 1989
//
// 2007-05-30, CSH, University of Freiburg
//
// accompanies the publication:
// Schmidt-Hieber C, Jonas P, Bischofberger J (2007)
// Subthreshold Dendritic Signal Processing and Coincidence Detection 
// in Dentate Gyrus Granule Cells. J Neurosci 27:8430-8441
//
// send bug reports and suggestions to christoph.schmidt-hieber@uni-freiburg.de
// ----------------------------------------------------------------------------

// spine:
create spine[2]
forsec "spine" {
	insert pas
	e_pas = 0
	cm = actCell.somaLoc.secRef.sec.cm 
	g_pas = actCell.somaLoc.secRef.sec.g_pas
	Ra = actCell.somaLoc.secRef.sec.Ra 
}

spine[0] {
	// neck:
	L=0.7
	diam=0.18
}

spine [1] {
	// head:
	L=0.5
	diam=0.5	
}

connect spine[1](0.0), spine[0](1.0)