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Model of DARPP-32 phosphorylation in striatal medium spiny neurons (Lindskog et al. 2006)
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The work describes a model of how transient calcium and dopamine inputs might affect phosphorylation of DARPP-32 in the medium spiny neurons in the striatum. The model is relevant for understanding both the "three-factor rule" for synaptic plasticity in corticostriatal synapses, and also for relating reinforcement learning theories to biology.
Lindskog M, Kim M, Wikström MA, Blackwell KT, Kotaleski JH (2006) Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation.
PLoS Comput Biol
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Neostriatum medium spiny direct pathway GABA cell;
Long-term Synaptic Plasticity;
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Neostriatum medium spiny direct pathway GABA cell
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