Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Model Views
Simulation Platform
Accession:
114394
In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.
Reference:
1 .
Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment.
Nat Neurosci
11
:178-86
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Channel(s):
I Na,t;
I K;
I M;
I h;
Gap Junctions:
Receptor(s):
Gene(s):
HCN1;
HCN2;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Active Dendrites;
Axonal Action Potentials;
Action Potentials;
Implementer(s):
Kole, Maarten [m.kole at nin.knaw.nl];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,t
;
I K
;
I M
;
I h
;
Download the displayed file
/
NN_kole
readme.html
h.mod
*
Other models using h.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Km.mod
*
Other models using Km.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)
kv.mod
*
Other models using kv.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
State and location dependence of action potential metabolic cost (Hallermann et al., 2012)
Kv1.mod
*
Other models using Kv1.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
na.mod
*
Other models using na.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)
nax.mod
*
Other models using nax.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)
A3+AIS_original.hoc
figure6a.hoc
initiate_neuron.hoc
mosinit.hoc
panels.ses
screenshot.jpg
screenshot_adjust.jpg
screenshot_morphology.jpg
load_file("nrngui.hoc") load_file("figure6a.hoc")
Load Model View
Simulation Platform