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Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
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Accession:
116835
A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article.
Reference:
1 .
Diwakar S, Magistretti J, Goldfarb M, Naldi G, D'Angelo E (2009) Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells.
J Neurophysiol
101
:519-32
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum interneuron granule GLU cell;
Channel(s):
I A;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Active Dendrites;
Detailed Neuronal Models;
Axonal Action Potentials;
Action Potentials;
Intrinsic plasticity;
Implementer(s):
Diwakar, Shyam [shyam at amrita.edu];
Search NeuronDB
for information about:
Cerebellum interneuron granule GLU cell
;
I A
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
/
GrC
fig10
readme.html
AmpaCOD.mod
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
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GRC_KA.mod
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KCA.mod
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Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KIR.mod
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Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KM.mod
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Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KV.mod
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_LKG1.mod
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Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_LKG2.mod
*
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_NA.mod
*
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NmdaS.mod
*
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Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
Pregen.mod
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ComPanel.hoc
Grc_Cell.hoc
mosinit.hoc
Parametri.hoc
screenshot.jpg
simple.ses
Start.hoc
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