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Hodgkin-Huxley models of different classes of cortical neurons (Pospischil et al. 2008)
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Accession:
123623
"We review here the development of Hodgkin- Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected the four most prominent electrophysiological classes of neurons. These four classes are 'fast spiking', 'regular spiking', 'intrinsically bursting' and 'low-threshold spike' cells. For each class, we fit 'minimal' HH type models to experimental data. ..."
Reference:
1 .
Pospischil M, Toledo-Rodriguez M, Monier C, Piwkowska Z, Bal T, Frégnac Y, Markram H, Destexhe A (2008) Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.
Biol Cybern
99
:427-41
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Channel/Receptor;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,t;
I L high threshold;
I T low threshold;
I K;
I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Parameter Fitting;
Simplified Models;
Implementer(s):
Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I K
;
I M
;
Download the displayed file
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PospischilEtAl2008
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load_file("nrngui.hoc") load_file("rundemo.hoc") print "Select a cell then press Init & Run button"
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Bursting pyramidal cell
Fast-spiking interneuron
LTS pyramidal cell
Regular-spiking pyramidal cell
Repetitive bursting pyramidal cell
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