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Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)
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"... we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltageclamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an +1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons."
Lee SC, Hayashida Y, Ishida AT (2003) Availability of low-threshold Ca2+ current in retinal ganglion cells.
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Neuron or other electrically excitable cell;
Retina ganglion GLU cell;
I T low threshold;
Ion Channel Kinetics;
Hayashida, Yuki [yukih at cs.kumamoto-u.ac.jp];
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Retina ganglion GLU cell
I T low threshold
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