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Computer model of clonazepam's effect in thalamic slice (Lytton 1997)
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Accession:
12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 .
Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice.
Neuroreport
8
:3339-43
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Channel(s):
I Na,t;
I T low threshold;
I K;
I CAN;
Gap Junctions:
Receptor(s):
GabaA;
Gaba;
Gene(s):
Transmitter(s):
Gaba;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Bursting;
Therapeutics;
Epilepsy;
Calcium dynamics;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
GabaA
;
Gaba
;
I Na,t
;
I T low threshold
;
I K
;
I CAN
;
Gaba
;
/
lytton97b
README
AMPA.mod
calciumpump_destexhe.mod
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GABAA.mod
GABAB1.mod
GABALOW.mod
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IAHP_destexhe.mod
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presyn.mod
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ctl.dat
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decvec.hoc
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default.hoc
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disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
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xtmp
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