MicrocircuitDB: Computer model of clonazepam's effect in thalamic slice (Lytton 1997)

Computer model of clonazepam's effect in thalamic slice (Lytton 1997)

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Accession:12631

Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 . Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]

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Model Type:	Realistic Network;
Brain Region(s)/Organism:	Thalamus;
Cell Type(s):	Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell;
Channel(s):	I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s):	GabaA; Gaba;
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	NEURON;
Model Concept(s):	Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s):	Lytton, William [bill.lytton at downstate.edu];