MicrocircuitDB: CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)

CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)

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Accession:126776

The model demonstrates that CA1 pyramidal neurons support rebound spikes mediated by hyperpolarization-activated inward current (Ih), and normally masked by A-type potassium channels (KA). Partial KA reduction confined to one or few branches of the apical tuft may be sufficient to elicit a local spike following a train of synaptic inhibition. These data suggest that the plastic regulation of KA can provide a dynamic switch to unmask post-inhibitory spiking in CA1 pyramidal neurons, further increasing the signal processing power of the CA1 synaptic microcircuitry.
Reference:
1 . Ascoli GA, Gasparini S, Medinilla V, Migliore M (2010) Local control of postinhibitory rebound spiking in CA1 pyramidal neuron dendrites. J Neurosci 30:6434-42 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I h; I Potassium;
Gap Junctions:
Receptor(s):	Gaba;
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Intrinsic plasticity; Synaptic Integration;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];