MicrocircuitDB: CA3 pyramidal neuron (Safiulina et al. 2010)

Accession:126814

In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses.
Reference:
1 . Safiulina VF, Caiati MD, Sivakumaran S, Bisson G, Migliore M, Cherubini E (2010) Control of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus. Front Synaptic Neurosci 2:1 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Synapse; Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA3 pyramidal GLU cell;
Channel(s):	I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Bursting; Temporal Pattern Generation; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Spike Frequency Adaptation;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: Hippocampus CA3 pyramidal GLU cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium; Gaba; Glutamate;