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Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
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Accession:
127021
Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
Reference:
1 .
Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase.
Neuropsychopharmacology
35
:1984-96
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Electrogenic pump;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum golgi cell;
Channel(s):
Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
HCN1;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Detailed Neuronal Models;
Markov-type model;
Alcohol Use Disorder;
Implementer(s):
Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB
for information about:
Na/K pump
;
Download the displayed file
/
Golgi_cell_NaKATPAse
sessions
README.html
Golgi_BK.mod
*
Other models using Golgi_BK.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_Ca_HVA.mod
*
Other models using Golgi_Ca_HVA.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_Ca_LVA.mod
*
Other models using Golgi_Ca_LVA.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)
Golgi_CALC.mod
*
Other models using Golgi_CALC.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_CALC_ca2.mod
*
Other models using Golgi_CALC_ca2.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_hcn1.mod
*
Other models using Golgi_hcn1.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_hcn2.mod
*
Other models using Golgi_hcn2.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_KA.mod
*
Other models using Golgi_KA.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)
Golgi_KM.mod
*
Other models using Golgi_KM.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_KV.mod
*
Other models using Golgi_KV.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_lkg.mod
*
Other models using Golgi_lkg.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_Na.mod
*
Other models using Golgi_Na.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)
Golgi_NaP.mod
*
Other models using Golgi_NaP.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_NaR.mod
*
Other models using Golgi_NaR.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_SK2.mod
*
Other models using Golgi_SK2.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
K_conc.mod
*
Other models using K_conc.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Na_conc.mod
*
Other models using Na_conc.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Pregen.mod
*
Other models using Pregen.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
pump.mod
Synapse.mod
*
Other models using Synapse.mod:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Channel_dynamics.hoc
*
Other models using Channel_dynamics.hoc:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Golgi_ComPanel.hoc
*
Other models using Golgi_ComPanel.hoc:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Golgi_count.txt
Golgi_Pump_Ouabain.ses
Golgi_template.hoc
mosinit.hoc
nerst
Save_data.hoc
*
Other models using Save_data.hoc:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Screenshot20100716_4.02.55PM.png
Start_Golgi_Ouabain.hoc
Synapses.hoc
*
Other models using Synapses.hoc:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
utils.hoc
*
Other models using utils.hoc:
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
441.000000
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