Basal ganglia network model of subthalamic deep brain stimulation (Hahn and McIntyre 2010)

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Accession:127388
Basal ganglia network model of parkinsonian activity and subthalamic deep brain stimulation in non-human primates from the article Instructions are provided in the README.txt file. Contact hahnp@ccf.org if you have any questions about the implementation of the model. Please include "ModelDB - BGnet" in the subject heading.
Reference:
1 . Hahn PJ, McIntyre CC (2010) Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation. J Comput Neurosci 28:425-41 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Subthalamus nucleus projection neuron; Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Bursting; Parkinson's; Deep brain stimulation;
Implementer(s): Hahn, Philip [hahnp at ccf.org];
Search NeuronDB for information about:  Dopamine; Gaba; Glutamate;
//-----------------------------------------------------------------------------------------------------
// IDs and counts

10		numSTN
30 		numGPe
10		numGPi
 
1		numSTNGPe		// each GPe contacted by numSTNGPe presyn STN cells, etc...
10		numGPeGPe
6		numGPeSTN
3		numGPeGPi
4		numSTNGPi
7		numCtxSTN
7		numStrGPe
7		numStrGPi
1		numGPiTha

3		divSTNGPe		// each STN contacts divSTNGPe postsyn GPe cells, etc...
10		divGPeGPe
2		divGPeSTN
1		divGPeGPi
4		divSTNGPi
1		divGPiTha


//-----------------------------------------------------------------------------------------------------
// bias currents

0.0336	iBiasSTN
0.1578	iBiasGPe
0.00653	iBiasGPi


//-----------------------------------------------------------------------------------------------------
// cell to cell connection parameters

0.0826	gmaxSTNGPe
0.0322	gmaxGPeGPe
0.0645	gmaxGPeSTN
0.0384	gmaxGPeGPi
0.1644	gmaxSTNGPi
0.0		gmaxGPiTha

1.25		gDA_STNGPe
1		gDA_GPeGPe
1.25		gDA_GPeSTN
1.25		gDA_GPeGPi
1		gDA_STNGPi
0.0		gDA_GPiTha

// THESE NEED TO BE SELECTED BASED ON EXPERIMENTAL/ANATOMICAL DATA ***********************************
4		delSTNGPe
4		delGPeGPe
4		delGPeSTN
4		delGPeGPi
4		delSTNGPi
4		delGPiTha


//-----------------------------------------------------------------------------------------------------
// higher level input connection parameters

75		imnCtxSTN
15		isdCtxSTN
4		bmnCtxSTN
1		bsdCtxSTN
25		bdmnCtxSTN
5		bdsdCtxSTN

75		imnStrGPe
15		isdStrGPe
4		bmnStrGPe
1		bsdStrGPe
25		bdmnStrGPe
5		bdsdStrGPe

150		imnStrGPi
30		isdStrGPi
4		bmnStrGPi
1		bsdStrGPi
25		bdmnStrGPi
5		bdsdStrGPi

0.25		probCtxSTN.x0
0.25		probCtxSTN.x1
0.25		probCtxSTN.x2
0.25		probCtxSTN.x3
0.25		probCtxSTN.x4
0.25		probCtxSTN.x5
0.25		probCtxSTN.x6

0.25		probStrGPe.x0
0.25		probStrGPe.x1
0.25		probStrGPe.x2
0.25		probStrGPe.x3
0.25		probStrGPe.x4
0.25		probStrGPe.x5
0.25		probStrGPe.x6

0.25		probStrGPi.x0
0.25		probStrGPi.x1
0.25		probStrGPi.x2
0.25		probStrGPi.x3
0.25		probStrGPi.x4
0.25		probStrGPi.x5
0.25		probStrGPi.x6

0.0865	gmaxCtxSTN
0.0557	gmaxStrGPe
0.05		gmaxStrGPi

1.25		gDA_CtxSTN
1.25		gDA_StrGPe
1		gDA_StrGPi

// THESE NEED TO BE SELECTED BASED ON EXPERIMENTAL/ANATOMICAL DATA ***********************************
4		delCtxSTN
4		delStrGPe
4		delStrGPi



//-----------------------------------------------------------------------------------------------------
// DBS parameters

2500		dbs_del
2500		dbs_dur
10		dbs_direct_amp
0.25		dbs_direct_pw
.15		dbs_ad_amp
2		dbs_ad_pw
7.35		dbs_period		// _136_ Hz