L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)

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"... L5b pyramidal cells have been the subject of extensive experimental and modeling studies, yet conductance-based models of these cells that faithfully reproduce both their perisomatic Na+-spiking behavior as well as key dendritic active properties, including Ca2+ spikes and back-propagating action potentials, are still lacking. Based on a large body of experimental recordings from both the soma and dendrites of L5b pyramidal cells in adult rats, we characterized key features of the somatic and dendritic firing and quantified their statistics. We used these features to constrain the density of a set of ion channels over the soma and dendritic surface via multi-objective optimization with an evolutionary algorithm, thus generating a set of detailed conductance-based models that faithfully replicate the back-propagating action potential activated Ca2+ spike firing and the perisomatic firing response to current steps, as well as the experimental variability of the properties. ... The models we present provide several experimentally-testable predictions and can serve as a powerful tool for theoretical investigations of the contribution of single-cell dynamics to network activity and its computational capabilities. "
1 . Hay E, Hill S, Schürmann F, Markram H, Segev I (2011) Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS Comput Biol 7:e1002107 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I M; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Hay, Etay [etay.hay at mail.huji.ac.il];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I M; I h; I K,Ca; I Calcium; I A, slow;
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
epsp.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
NaTs2_t.mod *
SK_E2.mod *
SKv3_1.mod *
: SK-type calcium-activated potassium current
: Reference : Kohler et al. 1996

       SUFFIX SK_E2
       USEION k READ ek WRITE ik
       USEION ca READ cai
       RANGE gSK_E2bar, gSK_E2, ik

      (mV) = (millivolt)
      (mA) = (milliamp)
      (mM) = (milli/liter)

          v            (mV)
          gSK_E2bar = .000001 (mho/cm2)
          zTau = 1              (ms)
          ek           (mV)
          cai          (mM)

         ik            (mA/cm2)
         gSK_E2	       (mho/cm2)

      z   FROM 0 TO 1

           SOLVE states METHOD cnexp
           gSK_E2  = gSK_E2bar * z
           ik   =  gSK_E2 * (v - ek)

        z' = (zInf - z) / zTau

PROCEDURE rates(ca(mM)) {
          if(ca < 1e-7 (mM)){
	              ca = ca + 1e-07 (mM)
          zInf = 1/(1 + (0.00043 (mM)/ ca)^4.8)

        z = zInf