Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Versions
Accession:
141505
This model is an extension of a model ( http://modeldb.yale.edu/138379 ) recently published in Frontiers in Computational Neuroscience. This model consists of 4700 event-driven, rule-based neurons, wired according to anatomical data, and driven by both white-noise synaptic inputs and a sensory signal recorded from a rat thalamus. Its purpose is to explore the effects of cortical damage, along with the repair of this damage via a neuroprosthesis.
Reference:
1 .
Kerr CC, Neymotin SA, Chadderdon GL, Fietkiewicz CT, Francis JT, Lytton WW (2012) Electrostimulation as a prosthesis for repair of information flow in a computer model of neocortex.
IEEE Trans Neural Syst Rehabil Eng
20
:153-60
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiny stellate cell;
Channel(s):
I Chloride;
I Sodium;
I Potassium;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gaba;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Deep brain stimulation;
Information transfer;
Brain Rhythms;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Kerr, Cliff [cliffk at neurosim.downstate.edu];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
GabaA
;
AMPA
;
NMDA
;
Gaba
;
I Chloride
;
I Sodium
;
I Potassium
;
Gaba
;
Glutamate
;
/
neuroprosthesis
README
infot.mod
*
Other models using infot.mod:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic information transfer in computer models of neocortical columns (Neymotin et al. 2010)
intf6_.mod
*
Other models using intf6_.mod:
Computational Surgery (Lytton et al. 2011)
intfsw.mod
*
Other models using intfsw.mod:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic information transfer in computer models of neocortical columns (Neymotin et al. 2010)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
misc.mod
*
Other models using misc.mod:
Computational Surgery (Lytton et al. 2011)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
JitCon: Just in time connectivity for large spiking networks (Lytton et al. 2008)
NEURON interfaces to MySQL and the SPUD feature extraction algorithm (Neymotin et al. 2008)
Synaptic information transfer in computer models of neocortical columns (Neymotin et al. 2010)
The virtual slice setup (Lytton et al. 2008)
nstim.mod
*
Other models using nstim.mod:
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
JitCon: Just in time connectivity for large spiking networks (Lytton et al. 2008)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
The virtual slice setup (Lytton et al. 2008)
Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)
staley.mod
*
Other models using staley.mod:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
stats.mod
*
Other models using stats.mod:
Computational Surgery (Lytton et al. 2011)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
vecst.mod
*
Other models using vecst.mod:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
batch.hoc
boxes.hoc
bsmart.py
col.hoc
comparecausality.py
comparerasters.py
declist.hoc
decmat.hoc
*
Other models using decmat.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
decnqs.hoc
*
Other models using decnqs.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
decvec.hoc
default.hoc
*
Other models using default.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
drline.hoc
*
Other models using drline.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
filtutils.hoc
flexinput.hoc
grvec.hoc
infot.hoc
*
Other models using infot.hoc:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
init.hoc
intfsw.hoc
labels.hoc
local.hoc
*
Other models using local.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
misc.h
*
Other models using misc.h:
Computational Surgery (Lytton et al. 2011)
Synaptic information transfer in computer models of neocortical columns (Neymotin et al. 2010)
mosinit.hoc
network.hoc
nload.hoc
nqs.hoc
nqsnet.hoc
nrnoc.hoc
params.hoc
pyhoc.py
ratlfp.dat
*
Other models using ratlfp.dat:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
run.hoc
runsim
setup.hoc
*
Other models using setup.hoc:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
simctrl.hoc
*
Other models using simctrl.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
spkts.hoc
*
Other models using spkts.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
staley.hoc
*
Other models using staley.hoc:
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
stats.hoc
*
Other models using stats.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
stdgui.hoc
*
Other models using stdgui.hoc:
Computational Surgery (Lytton et al. 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
syncode.hoc
*
Other models using syncode.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
updown.hoc
*
Other models using updown.hoc:
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
xgetargs.hoc
*
Other models using xgetargs.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
File not selected
<- Select file from this column.
