MicrocircuitDB: Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

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Accession:143604

A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Reference:
1 . Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340:759-62 [PubMed]

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Model Type:	Synapse; Dendrite;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortex L2/3 pyramidal GLU cell;
Channel(s):	I Na,t; I L high threshold; I K;
Gap Junctions:
Receptor(s):	GabaA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Dendritic Action Potentials; Influence of Dendritic Geometry;
Implementer(s):	Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];