MicrocircuitDB: State and location dependence of action potential metabolic cost (Hallermann et al., 2012)

State and location dependence of action potential metabolic cost (Hallermann et al., 2012)

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Accession:144526

With this model of a layer 5 pyramidal neuron the state and location dependence of the ATP usage and the metabolic efficiency of action potentials can be analyzed. Model parameters were constrained by direct subcellular recordings at dendritic, somatic and axonal compartments.
Reference:
1 . Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012) State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci 15:1007-14 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Action Potentials;
Implementer(s):	Hallermann, Stefan [hallermann at medizin.uni-leipzig.de]; Kole, Maarten [m.kole at nin.knaw.nl];