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CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
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The model predicts possible therapeutic treatments of Alzheimers's Disease in terms of pharmacological manipulations of channels' kinetic and activation properties. The results suggest how and which mechanism can be targeted by a drug to restore the original firing conditions. The simulations reproduce somatic membrane potential in control conditions, when 90% of membrane is affected by AD (Fig.4A of the paper), and after treatment (Fig.4B of the paper).
Culmone V, Migliore M (2012) Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments.
Front Comput Neurosci
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Hippocampus CA1 pyramidal GLU cell;
Detailed Neuronal Models;
Migliore, Michele [Michele.Migliore at Yale.edu];
Culmone, Viviana [viviana.abigail at hotmail.it];
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Hippocampus CA1 pyramidal GLU cell
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