Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Versions
Accession:
147141
Learning in the brain requires complementary mechanisms: potentiation and activity-dependent homeostatic scaling. We introduce synaptic scaling to a biologically-realistic spiking model of neocortex which can learn changes in oscillatory rhythms using STDP, and show that scaling is necessary to balance both positive and negative changes in input from potentiation and atrophy. We discuss some of the issues that arise when considering synaptic scaling in such a model, and show that scaling regulates activity whilst allowing learning to remain unaltered.
Reference:
1 .
Rowan MS, Neymotin SA (2013) Synaptic Scaling Balances Learning in a Spiking Model of Neocortex
Adaptive and Natural Computing Algorithms
, Tomassini M, Antonioni A, Daolio F, Buesser P, ed. pp.20
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiny stellate cell;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Synaptic Plasticity;
Long-term Synaptic Plasticity;
Learning;
STDP;
Homeostasis;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Rowan, Mark [m.s.rowan at cs.bham.ac.uk];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
GabaA
;
AMPA
;
NMDA
;
Gaba
;
Glutamate
;
/
stdpscalingpaper
batchscripts
mod
README
alz.hoc
autotune.hoc
*
Other models using autotune.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
basestdp.hoc
*
Other models using basestdp.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
batch.hoc
*
Other models using batch.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
batch2.hoc
*
Other models using batch2.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
batchcommon
checkirreg.hoc
*
Other models using checkirreg.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
clusterrun.sh
col.dot
*
Other models using col.dot:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
col.hoc
*
Other models using col.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
comppowspec.hoc
*
Other models using comppowspec.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
condisconcellfig.hoc
*
Other models using condisconcellfig.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
condisconpowfig.hoc
*
Other models using condisconpowfig.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
declist.hoc
*
Other models using declist.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
decmat.hoc
*
Other models using decmat.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
decnqs.hoc
*
Other models using decnqs.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
decvec.hoc
*
Other models using decvec.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
default.hoc
*
Other models using default.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
drline.hoc
*
Other models using drline.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
e2hubsdisconpow.hoc
*
Other models using e2hubsdisconpow.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
e2incconpow.hoc
*
Other models using e2incconpow.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
filtutils.hoc
*
Other models using filtutils.hoc:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
geom.hoc
*
Other models using geom.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
graphplug.hoc
*
Other models using graphplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
grvec.hoc
*
Other models using grvec.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
init.hoc
*
Other models using init.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
labels.hoc
*
Other models using labels.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
load.hoc
*
Other models using load.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
local.hoc
*
Other models using local.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
makepopspikenq.hoc
*
Other models using makepopspikenq.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
matfftpowplug.hoc
*
Other models using matfftpowplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
matpmtmplug.hoc
*
Other models using matpmtmplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
matpmtmsubpopplug.hoc
*
Other models using matpmtmsubpopplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
matspecplug.hoc
*
Other models using matspecplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
network.hoc
*
Other models using network.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
nload.hoc
*
Other models using nload.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
nqpplug.hoc
*
Other models using nqpplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
nqs.hoc
*
Other models using nqs.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
nqsnet.hoc
*
Other models using nqsnet.hoc:
Computational Surgery (Lytton et al. 2011)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
nrnoc.hoc
*
Other models using nrnoc.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Computational Surgery (Lytton et al. 2011)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
params.hoc
plot.py
plotbatch.sh
plotbatchcluster.sh
powchgtest.hoc
*
Other models using powchgtest.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
python.hoc
*
Other models using python.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
pywrap.hoc
*
Other models using pywrap.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
redE2.hoc
*
Other models using redE2.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
run.hoc
runsim.sh
setup.hoc
*
Other models using setup.hoc:
Computational Surgery (Lytton et al. 2011)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
shufmua.hoc
*
Other models using shufmua.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
sim.hoc
simctrl.hoc
*
Other models using simctrl.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
spkts.hoc
*
Other models using spkts.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
stats.hoc
*
Other models using stats.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
stdpscaling.hoc
syncode.hoc
*
Other models using syncode.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
vsampenplug.hoc
*
Other models using vsampenplug.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
writedata.hoc
xgetargs.hoc
*
Other models using xgetargs.hoc:
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
File not selected
<- Select file from this column.
