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Altered complexity in layer 2/3 pyramidal neurons (Luuk van der Velden et al. 2012)
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Accession:
147514
" ... Our experimental results show that hypercomplexity of the apical dendritic tuft of layer 2/3 pyramidal neurons affects neuronal excitability by reducing the amount of spike frequency adaptation. This difference in firing pattern, related to a higher dendritic complexity, was accompanied by an altered development of the afterhyperpolarization slope with successive action potentials. Our abstract and realistic neuronal models, which allowed manipulation of the dendritic complexity, showed similar effects on neuronal excitability and confirmed the impact of apical dendritic complexity. Alterations of dendritic complexity, as observed in several pathological conditions such as neurodegenerative diseases or neurodevelopmental disorders, may thus not only affect the input to layer 2/3 pyramidal neurons but also shape their firing pattern and consequently alter the information processing in the cortex."
Reference:
1 .
van der Velden L, van Hooft JA, Chameau P (2012) Altered dendritic complexity affects firing properties of cortical layer 2/3 pyramidal neurons in mice lacking the 5-HT3A receptor.
J Neurophysiol
108
:1521-8
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex spiking regular (RS) neuron;
Channel(s):
Ca pump;
Gap Junctions:
Receptor(s):
5-HT3;
Gene(s):
Transmitter(s):
Serotonin;
Simulation Environment:
NEURON;
Model Concept(s):
Influence of Dendritic Geometry;
Implementer(s):
van der Velden, Luuk [l.j.j.vandervelden at uva.nl];
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for information about:
5-HT3
;
Ca pump
;
Serotonin
;
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dendritic_complexity
README.html
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load_file("nrngui.hoc") load_file("altered_complexity_model.hoc")
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