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Effects of Chloride accumulation and diffusion on GABAergic transmission (Jedlicka et al 2011)
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"In the CNS, prolonged activation of GABA(A) receptors (GABA(A)Rs) has been shown to evoke biphasic postsynaptic responses, consisting of an initial hyperpolarization followed by a depolarization. A potential mechanism underlying the depolarization is an acute chloride (Cl(-)) accumulation resulting in a shift of the GABA(A) reversal potential (E(GABA)). The amount of GABA-evoked Cl(-) accumulation and accompanying depolarization depends on presynaptic and postsynaptic properties of GABAergic transmission, as well as on cellular morphology and regulation of Cl(-) intracellular concentration ([Cl(-)](i)). To analyze the influence of these factors on the Cl(-) and voltage behavior, we studied spatiotemporal dynamics of activity-dependent [Cl(-)](i) changes in multicompartmental models of hippocampal cells based on realistic morphological data. ..."
Jedlicka P, Deller T, Gutkin BS, Backus KH (2011) Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission.
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Neuron or other electrically excitable cell;
Dentate gyrus granule GLU cell;
Influence of Dendritic Geometry;
Short-term Synaptic Plasticity;
Jedlicka, Peter [jedlicka at em.uni-frankfurt.de];
Mohapatra, Namrata [mohapatra at em.uni-frankfurt.de];
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Dentate gyrus granule GLU cell
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Dentate gyrus granule cell: subthreshold signal processing (Schmidt-Hieber et al. 2007)
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