MicrocircuitDB: CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)

CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)

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Accession:148646

" ... the investigation of AP backpropagation and its functional roles has greatly benefitted from computational models that use biophysically and morphologically accurate implementations. ..." This model entry recreates figures 2 and 4 from the paper illustrating how conductance densities of voltage gated channels (fig 2) and the timing of synaptic input with backpropagating action potentials (fig 4) affects membrane voltage trajectories.
Reference:
1 . Gasparini S,Migliore M (2015) Action Potential Backpropagation Encyclopedia of Computational Neuroscience, (Jaeger D:Jung R, ed. pp.133

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Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Action Potentials; Synaptic Integration;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];