MicrocircuitDB: Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)

Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)

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Accession:149100

The authors found that linearly scaling the ion channel conductance densities of a reference model with the conductance load in 28 3D reconstructed layer 5 thick-tufted pyramidal cells was necessary to match the experimental statistics of these cells electrical firing properties.
Reference:
1 . Hay E, Schürmann F, Markram H, Segev I (2013) Preserving axosomatic spiking features despite diverse dendritic morphology. J Neurophysiol 109:2972-81 [PubMed]

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Model Type:	Neuron or other electrically excitable cell; Axon; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Parameter Fitting; Action Potentials; Parameter sensitivity;
Implementer(s):	Hay, Etay [etay.hay at mail.huji.ac.il];