KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)

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The output of the cerebellum to the motor axis of the central nervous system is orchestrated mainly by synaptic inputs and intrinsic pacemaker activity of deep cerebellar nuclear (DCN) projection neurons. Herein, we demonstrate that the soma of these cells is enriched with KV1 channels produced by mandatory multi-merization of KV1.1, 1.2 alpha andKV beta2 subunits. Being constitutively active, the K+ current (IKV1) mediated by these channels stabilizes the rate and regulates the temporal precision of self-sustained firing of these neurons. ... Through the use of multi-compartmental modelling and ... the physiological significance of the described functions for processing and communication of information from the lateral DCN to thalamic relay nuclei is established.
1 . Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum deep nucleus neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Kv1.1 KCNA1; Kv1.2 KCNA2;
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Intrinsic plasticity; Rebound firing;
Implementer(s): Steuber, Volker [v.steuber at herts.ac.uk]; Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
CaConc.mod *
CaHVA.mod *
CalConc.mod *
CaLVA.mod *
DCNsyn.mod *
DCNsynGABA.mod *
DCNsynNMDA.mod *
fKdr.mod *
GammaStim.mod *
h.mod *
Ifluct8.mod *
NaF.mod *
NaP.mod *
pasDCN.mod *
SK.mod *
sKdr.mod *
TNC.mod *
DCN_mechs1.hoc *
DCN_morph.hoc *
TITLE Intracellular calcium concentration from the CaLVA channel in deep cerebellar nucleus (DCN) neuron
    This mechanism keeps track of intracellular calcium entering the cell through
    the CaLVA channel, with the sole purpose of setting the conductance of the 
    channel which uses the GHK equation to calculate current flow.
    The mechanism is a copy of the CaConc.mod and thus uses the same method of
    tracking Ca concentration merely in a hypothetical shell below the membrane
    of the cell.

    SUFFIX CalConc
    USEION cal READ ical WRITE cali VALENCE 2    
    RANGE cali, kCal, depth
    GLOBAL tauCal

    (molar) = (1 / liter)
    (mM) = (millimolar)
    (mV) = (millivolt)
    (mA) = (milliamp)
    PI = (pi) (1)

    : qdeltat has been skipped here and is used via the division of this NMODL's
    : tauCal when it's inserted (in hoc).

    : kCa in the following is given for the soma and shall be adjusted
    : from hoc when the CaConc model is inserted in a dendrite: 1.04e-6
    : in the dendritic compartments units. kCa is here given as 1 / coulombs
    : instead of moles / coulomb as in the GENESIS code since mole
    : in NEURON simply equals the number 6.022 * 10e23
    kCal = 3.45e-7 (1/coulomb)
    tauCal = 70 (ms)
    caliBase = 50e-6 (mM) : the resting intracellular calcium conc =50 nM
    depth = 0.2 (micron)

    C (kilo / m3 / s)
    D (kilo / m3 / s)
    ical (mA/cm2)

    cali (mM)

    cali = caliBase

    SOLVE states METHOD cnexp

    C = (cali - caliBase) / tauCal
	D = - kCal / depth * ical * (1e4)
    cali' = D - C